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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
05 - 27 January 2004
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
- Lot/batch No.: 00410155
- Analytical purity: 96%
- Expiration date of the lot/batch: 2004-05-05
- Storage condition of test material: At room temperature at about 20°C.
Key result
Type:
log Pow
Partition coefficient:
1.6
Temp.:
20 °C
pH:
5

 Number of analyses  Retention time (min)  k'  log k'  log Pow
 1 3.50  0.82   -0.08599  1.7
 2  3.50  0.82  -0.08654  1.6
 3  3.50  0.82  -0.08654  1.6

The main value of log Pow is 1.6.

Conclusions:
The log Pow of T002251 was determined by the HPLC method to be 1.6 (n-octanol/water partition coefficient).

Description of key information

The partition coefficient of T002251 was determined in a GLP study performed according to OECD Guideline 117 and EU Method A.8. (K1, Tognucci, 2004) using the HPLC method. Resulting in a log Pow value of 1.6 (n-octanol/water partition coefficient) at pH 5 and 20°C.

Key value for chemical safety assessment

Log Kow (Log Pow):
1.6
at the temperature of:
20 °C

Additional information