Registration Dossier
Registration Dossier
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EC number: 203-596-2 | CAS number: 108-58-7
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics, other
- Remarks:
- Toxicokinetik assumption
- Type of information:
- other: Toxicokinetik assumption
- Adequacy of study:
- weight of evidence
- Objective of study:
- other: Toxicokinetik assumption
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Toxicokinetik assumption
Reference
Description of key information
There are no experimental toxicokinetic data available for the substance and this statement is based on available data as physico-chemical data and toxicological data. The assumption was conducted based on the REACH ECHA “Guidance on information requirements and chemical safety assessment chapter R.7c” of the ECHA guidance document (Version 3.0, June 2017).
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
Estimation of accumulation:
In general substances with high log P values have long biological half-lives. Substances with log P values of 3 and less would be unlikely to accumulate with the repeated intermittent exposure patterns normally encountered in the workplace but may be accumulate if exposures are continuous.
m-phenylene di(acetate) has a log Pow of 1.87 and a high water solubility of 7.4 g/L.
The physicochemical properties of m-phenylene di(acetate) do not favour substantial accumulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
