m-phenylene di(acetate)

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

yes

Remarks:

Because the test item seems to be susceptible to hydrolysis (preliminary test) the test design differs from the Guideline. Instead of solving for 24, 48 and 72 hours at 30 °C, the period of testing was shortened and the temperature reduced.

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

yes

Remarks:

Because the test item seems to be susceptible to hydrolysis (preliminary test) the test design differs from the Guideline. Instead of solving for 24, 48 and 72 hours at 30 °C, the period of testing was shortened and the temperature reduced.

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7840 (Water Solubility)

Deviations:

yes

Remarks:

Because the test item seems to be susceptible to hydrolysis (preliminary test) the test design differs from the Guideline. Instead of solving for 24, 48 and 72 hours at 30 °C, the period of testing was shortened and the temperature reduced.

Principles of method if other than guideline:

In a preliminary test, the water solubility of the test item was found to be > 10-2 g/L (approximately 7 g/L). Therefore the flask method was chosen for the determination of the water solubility.
For the main test, a quantity of the test item necessary for saturation is dissolved in demineralized water. The vessels are stoppered and stirred on a magnetic stirrer for 6 h, 14 h and 24 h at 20 °C in a temperature controlled water bath. After phase separation by filtration with a disposable syringe filter and/or centrifugation, the concentration of the test item in the aqueous test solutions is determined by HPLC-analysis with UV-detection.

GLP compliance:

yes

Type of method:

flask method

Specific details on test material used for the study:

Date of receipt: 2017-02-06
Expiry date: 2018-01-20
Batch number : 0900250090

Water solubility:

7.423 g/L

Conc. based on:

test mat.

Incubation duration:

6 h

Temp.:

20 °C

pH:

3.5

Remarks on result:

other: Flask A

Water solubility:

7.402 g/L

Conc. based on:

test mat.

Incubation duration:

14 h

Temp.:

20 °C

pH:

3.6

Remarks on result:

other: Flask B

Water solubility:

7.367 g/L

Conc. based on:

test mat.

Incubation duration:

24 h

Temp.:

20 °C

pH:

3.6

Remarks on result:

other: Flask C

Key result

Water solubility:

7.4 g/L

Conc. based on:

test mat.

Incubation duration:

24 h

Temp.:

20 °C

pH:

>= 3.5 - <= 3.6

Remarks on result:

other: Mean value

Details on results:

The relative standard deviation between the single determinations is < 15 %.
The validity criteria have therefore been met.

Test item concentrations

	Flask A [mg]	Flask B [mg]	Flask C [mg]
Initial weight in mg	3505.7	3501.2	3508.2
Volume of water in mL	100	100	100

In a preliminary test the concentration found was 7.03 g/L. Therefore the concentration for the main test was set to 35 g/L. This corresponds to 5 times the concentration found in the pretest.

Conclusions:

Water solubility of the test item Resorcindiacetat at 20 °C is 7.4 g/L.

Executive summary:

The water solubility of the test item Resorcindiacetat in demineralized water was determined with the shake flask method at 20 °C according to OECD 105. The concentration of the test item in the aqueous test solutions was determined by HPLC analysis with UV detection. Water solubility of Resorcindiacetat at 20 °C is 7.4 g/L. The relative standard deviation between the single determinations is < 15 %. The validity criteria have therefore been met.

Description of key information

The water solubility of the test item Resorcindiacetat in demineralized water was determined with the shake flask method at 20 °C according to OECD 105. The concentration of the test item in the aqueous test solutions was determined by HPLC analysis with UV detection. Water solubility of Resorcindiacetat at 20 °C is 7.4 g/L. The relative standard deviation between the single determinations is < 15 %. The validity criteria have therefore been met.

Key value for chemical safety assessment

Water solubility:

7.4 g/L

at the temperature of:

20 °C