Registration Dossier

Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2017-01-13 - 2017-04-04 (experimental)
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2017
Report Date:
2017

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
March 23, 2006
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
August 24, 2009
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
Version / remarks:
August 1996
Deviations:
no
GLP compliance:
yes
Type of method:
effusion method: isothermal thermogravimetry

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder

Results and discussion

Vapour pressureopen allclose all
Key result
Temp.:
20 °C
Vapour pressure:
< 0 Pa
Key result
Temp.:
25 °C
Vapour pressure:
< 0 Pa

Applicant's summary and conclusion

Conclusions:
The GLP study was performed according to EU method A.4 and OCED 104 without deviations and therefore reliability of Klimisch 1 has been assigned. The vapour pressure of the substance has been determined to be < 8.4 × 10E-7 Pa at 20 °C and < 2.2 × 10E-6 Pa at 25 °C.
Executive summary:

The vapour pressure of the test item has been determined in a GLP study according to EU Method A.4, OECD 104 and OPPTS 830.7950 using the isothermal thermogravimetric effusion method. The method is validated in the range 10-8 - 103 Pa using a set of five reference substances with known vapour pressures. The weight loss of the test item was measured continuously as a function of time at defined isothermal temperatures. The evaporation rate of the test item (vT) was calculated from the weight loss of the compound. The PT values at the defined isothermal temperatures were determined using the vapour pressure equation with the constants c and d specific for the experimental arrangement. Linear regression analysis of the log PT values and 1/T was performed using a least squares method. The PT values of the test item at 20°C and 25°C were determined using the vapour pressure regression curve. The vapour pressure of the test item at 20°C (293K) and 25°C (298K) was:

 20 °C     25 °C   
 [Pa]  [mm Hg]  [Pa]  [mm Hg]
 Test item  <8.4 x 10-7  <6.3 x 10-9  <2.2 x 10-6  <1.6 x 10-8