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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
01 December, 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
The study was conducted according to an internationally recognised method, and under GLP. No deviation was reported. Test substance is adequately specified. Therefore full validation applies.
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
2006
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
Commission Regulation (EC) No 761/2009 of 23. July 2009, published on 24. Aug. 2009
Deviations:
no
Principles of method if other than guideline:
Not applicable
GLP compliance:
yes (incl. certificate)
Remarks:
inspected on 13 and 14 October 2014 / signed on 08 April 2015
Type of method:
static method
Key result
Test no.:
#1
Temp.:
20 °C
Vapour pressure:
1 575 Pa
Key result
Test no.:
#2
Temp.:
25 °C
Vapour pressure:
1 959 Pa

Table 4.6/1: Measurement Values

1. Determination

increasing temperature

2. Determination

decreasing temperature

Temp. in °C

Pressure in hPa

Temp. in °C

Pressure in hPa

20.0

15.3

48.0

49.4

28.9

23.2

38.9

34.6

38.1

33.4

29.9

26.4

47.0

48.0

21.0

16.7

56.0

62.5

16.1

12.6

Table 4.6/2: Calculated values for 1/T and log P

n                  

Temperature T (°C)

Pressure P (hPa)

Temperature T (K)

1/T (1/K)

log P

log Pa

1

20.0

15.3

293.15

0.00341122

3.1847

2

28.9

23.2

302.05

0.00331071

3.3655

3

38.1

33.4

311.25

0.00321285

3.5237

4

47.0

48.0

320.15

0.00312354

3.6812

5

56.0

62.5

329.15

0.00303813

3.7959

6

48.0

49.4

321.15

0.00311381

3.6937

7

38.9

34.6

312.05

0.00320461

3.5391

8

29.9

26.4

303.05

0.00329979

3.4216

9

21.0

16.7

294.15

0.00339963

3.2227

10

16.1

12.6

289.25

0.00345722

3.1004

linear regression :

y = -1659.671699 x + 8.858654072

r² = 0.994666565  (> 0.95)

Table 4.6/3: Calculated Values for vapour pressure

Parameter

Value

Vapour Pressure (20 °C)

1575 Pa

Vapour Pressure (25 °C)

1959 Pa

 

The vapour pressure of the test item was measured using the static method as described in EU method A.4. Ten pairs temperature/vapour pressure were used to calculate a regression from which vapour pressure at ambient temperature could be estimated.

From the measured values, the vapour pressure of the test item was calculated as 1575 Pa at 20.0 °C and 1959 Pa at 25 °C. The values of the heating and cooling down phase showed good correspondence.

Therefore, the result of the study is considered valid.

Conclusions:
The vapour pressure of the test item was calculated as 1575 Pa at 20.0 °C and 1959 Pa at 25 °C.
These values represent the component with the highest vapour pressure.
Executive summary:

The vapour pressure of the test substance was measured under GLP according to OECD 104 / EU A4 guideline, static method. Ten pairs temperature/vapour pressure were used to calculate a regression in a temperature range of 16.1 – 56.0 °C, from which vapour pressure at ambient temperature could be estimated.

From the measured values, the vapour pressure of the test item was calculated as 1575 Pa at 20.0 °C and 1959 Pa at 25 °C.

These values represent the component with the highest vapour pressure.

Description of key information

The vapour pressure of the test item was calculated as 1575 Pa at 20.0 °C and 1959 Pa at 25 °C (interpolation).

These values represent the component with the highest vapour pressure.

Key value for chemical safety assessment

Vapour pressure:
1 959 Pa
at the temperature of:
25 °C

Additional information

A fully reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. Therefore, it is considered as a key study.