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EC number: 813-543-0 | CAS number: 73984-93-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Guideline study. No information about GLP compliance available. The study was conducted using skin that had been abraded (care was taken so as to only penetrate the stratum corneum and not the dermis). This deviates from the current OECD Guideline 402, however, this is not considered to affect the outcome of the study as the test material resulted in an LD50 of > 2000 mg/kg.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- This study was conducted using skin that had been abraded (care was taken so as to only penetrate the stratum corneum and not the dermis). However, this will not affect the outcome of the study.
- GLP compliance:
- not specified
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- 1,3,4-Thiadiazole-2(3H)-thione, 5-(tert-dodecyldithio)-
- EC Number:
- 813-543-0
- Cas Number:
- 73984-93-7
- Molecular formula:
- C14H26N2S4
- IUPAC Name:
- 1,3,4-Thiadiazole-2(3H)-thione, 5-(tert-dodecyldithio)-
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dutchland Laboratories, Denver, PA
- Weight at study initiation: 2.2 to 2.7 kg
- Fasting period before study: No
- Housing: Individually housed in stainless steel cages (61.0 x 45.5 x 42.0 cm)
- Diet: Rabbits were fed Purina Rabbit Chow Complete Blend (Ralston Purina Co.) ad libitum
- Water: ad libitum
- Acclimation period: 3 weeks
ENVIRONMENTAL CONDITIONS
- Temperature (°C): approx. 22
- Humidity (%): approx. 40 (relative)
- Photoperiod (hrs dark / hrs light): 12 / 12
IN-LIFE DATES:
12/3/81 – 12/18/81
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: An area of 240 cm2 on the back of each animal
- Type of wrap if used: gauze pad and plastic film covered by lint-free cloth towelling
REMOVAL OF TEST SUBSTANCE
- Washing (if done): 0.9 % sodium chloride
- Time after start of exposure: 24 h
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2000 mg/kg
- Concentration (if solution): applied undiluted
- Constant volume or concentration used: yes - Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5 male and 5 female
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observations were performed at least once a day; animals were weighed immediately prior to dosing
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Statistics:
- No statistics reported.
Results and discussion
- Preliminary study:
- No preliminary study reported.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None observed.
- Clinical signs:
- other: The test site was noted to be irritated during the 14 day observation period.
- Gross pathology:
- No details available.
- Other findings:
- Gross necropsy findings were normal
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- The test report describes a valid guideline study, without information about GLP compliance. The acute dermal LD50 was determined to be > 2000 mg/kg. Thus, the test substance can be considered as not acutely toxic via the dermal route.
- Executive summary:
An acute dermal study was conducted using a similar procedure to that described in the current OECD Guideline 402. The test material (CAS No. 73984 -93 -7) was applied at a dose of 2000 mg/kg to the backs of five male and five female rabbits. The substance was left in contact with the skin for 24 hours and then the test sites were washed with 0.9 % sodium chloride and the rabbits observed during this time and for 14 days after its removal. No rabbits died during the study, dermal irritation was present in all rabbits during the majority of the 14 day observation period following removal of the wrappings. Gross necropsy findings in all rabbits were within normal limits. The acute dermal LD50 was determined to be greater than 2000 mg/kg.
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