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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from 2017-04-18 to 2017-05-16
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Reference:
Composition 0
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
yes
Remarks:
refer to 'Principles of method if other than guideline'
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
yes
Remarks:
refer to 'Principles of method if other than guideline'
Qualifier:
according to
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Deviations:
yes
Remarks:
refer to 'Principles of method if other than guideline'
Principles of method if other than guideline:
As the water solubility of the test item determined in a preliminary test showed that the test item is very soluble, as a main test the Preliminary test (OECD 105) with visual detection at room temperature was performed.
GLP compliance:
yes (incl. certificate)
Type of method:
other: preliminary test (OECD 105), visual detection
Test material information:
Composition 1
Specific details on test material used for the study:
Batch No.: 0458507022_R_JM
Purity: 99.8 %
Key result
Water solubility:
> 835 g/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
0.5

Table 1. Water solubility test

Experiment 1

Experiment 2

x (g) Test Item added to 5 mL water

Observation

x (g) Test Item added to 5 mL water

Observation

5.0389

clear liquid phase

5.0968

clear liquid phase

6.0944

clear liquid phase

6.1011

clear liquid phase

7.1130

clear liquid phase

7.1083

clear liquid phase

8.1360

clear liquid phase

8.1107

clear liquid phase

9.2156

clear liquid phase

9.1332

clear liquid phase

10.2277

clear liquid phase

10.1399

clear liquid phase

11.2592

precipitation of test item

11.1724

precipitation of test item

The pH value of the clear liquid phase at the ca. 835 g/L (10.0277 g and 10.0091 g test item / 12 mL[ses1] ) concentration level was determined to be: 0.5.

Conclusions:
The water solubility of the test item was determined to be > 835 g/L (ca. 10 g / 12 mL) at room temperature based on the Preliminary Test (OECD 105).
Executive summary:

The water solubility was determined according to OECD 105, Regulation (EC) No. 440/2008 method A.6 and OPPTS 830.7840. In a preliminary test no saturated solution of the test item could not be prepared, therefore, the standard methods for determination of the water solubility are not feasible. Therefore, the water solubility of the test item was determined using the Preliminary test (OECD 105) with visual detection. 5 - 11 g test item were added to 5 mL water in 1 g steps. After each addition of an amount of test item, the mixture was shaken and was visually checked for any undissolved parts of the sample. The pH of each sample was recorded. The water solubility of the test substance was determined to be > 835 g/L (ca. 10 g / 12 mL) at room temperature based on the Preliminary Test (OECD 105) (pH 0.5).

Description of key information

The water solubility of the test item was determined to be > 835 g/L (ca. 10 g / 12 mL) at room temperature based on the Preliminary Test (OECD 105).

Key value for chemical safety assessment

Additional information

The water solubility was determined according to OECD 105, Regulation (EC) No. 440/2008 method A.6 and OPPTS 830.7840. In a preliminary test no saturated solution of the test item could not be prepared, therefore, the standard methods for determination of the water solubility are not feasible. Therefore, the water solubility of the test item was determined using the Preliminary test (OECD 105) with visual detection. 5 - 11 g test item were added to 5 mL water in 1 g steps. After each addition of an amount of test item, the mixture was shaken and was visually checked for any undissolved parts of the sample. The pH of each sample was recorded. The water solubility of the test substance was determined to be > 835 g/L (ca. 10 g / 12 mL) at room temperature based on the Preliminary Test (OECD 105) (pH 0.5).