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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from 2017-04-20 to 2018-02-08
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Reference:
Composition 0
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
effusion method: Knudsen cell
Test material information:
Composition 1
Key result
Temp.:
20 °C
Vapour pressure:
0 Pa
Temp.:
25 °C
Vapour pressure:
0 Pa

Observations

75 °C: At the first and second measurement of experiment 4, cell 1 was slightly contaminated. Therefore, the cell was meticulously cleaned and weighed. This weight was used as initial weight for the subsequent measurements. To avoid bias, this measurement was not used for calculations.

120 °C: At the first measurement of experiment 7, all cells were slightly contaminated. Therefore, the cells were meticulously cleaned and weighed. This weight was used as initial weight for the subsequent measurements. To avoid bias, this measurement was not used for calculations.

150 °C: At the first measurement all cells were empty.

Results

Experiment 1-4 (nominal temperature 30 - 75 °C) showed no reproducible weight loss. Therefore, they were not used for calculation. At the first measurement of 150 °C all cells were empty and the determination was finished.

Table 1. Experimental results

T

T

P

Stand. Dev. P

RSD P

°C

K

Pa

Pa

%

90.0

363.2

9.95E-02

2.85E-02

28.7%

105.0

378.2

3.51E-01

6.72E-02

19.2%

120.0

393.2

7.22E-01

4.31E-02

6.0%

135.0

408.2

2.32E+00

1.89E-01

8.2%

For the test item, the following vapour pressures at 20 °C and at 25 °C were calculated from the regression equation:

Vapour pressure at 20 °C:

1.38 * 10-4 Pa

Vapour pressure at 25 °C:

2.46 * 10-4 Pa

The vapour pressure of the test item was determined at eight different temperatures (30, 45, 60, 75, 90, 105, 120 and 135 °C) according to OECD 104 resp. EU A.4 using the effusion method (weight loss). Four experiments could be evaluated as they showed relevant and reproducible weight loss. All evaluated experiments showed good reproducibility, giving relative standard deviations of less than 29 % and good correlation. Therefore, the result of the test can be considered as valid.

Conclusions:
The vapour pressure of the test item was extrapolated from experimental data and was calculated to be 1.38E-4 Pa at 20 °C.
Executive summary:

A study was conducted according to OECD TG 104 and Regulation (EC) No 440/2008 method A.4 to determine the vapour pressure of the test item. The vapour pressure of the test item was determined at temperatures between 30 and 135 °C using the effusion method (Knudsen cell). For the evaluation the vapour pressure values in the range of 90 to 135 °C were used. The vapour pressure of the test item was calculated by extrapolation of the measured vapour pressure curve for the temperatures 20 and 25 °C. The vapour pressure was calculated to be 1.38E-4 Pa at 20 °C and 2.46E-4 Pa at 25 °C, respectively.

Description of key information

The vapour pressure of the test item was extrapolated from experimental data and was calculated to be 1.38E-4 Pa at 20 °C.

Key value for chemical safety assessment

Vapour pressure:
0 Pa
at the temperature of:
20 °C

Additional information

A study was conducted according to OECD TG 104 and Regulation (EC) No 440/2008 method A.4 to determine the vapour pressure of the test item. The vapour pressure of the test item was determined at temperatures between 30 and 135 °C using the effusion method (Knudsen cell). For the evaluation the vapour pressure values in the range of 90 to 135 °C were used. The vapour pressure of the test item was calculated by extrapolation of the measured vapour pressure curve for the temperatures 20 and 25 °C. The vapour pressure was calculated to be 1.38E-4 Pa at 20 °C and 2.46E-4 Pa at 25 °C, respectively.