Registration Dossier
Registration Dossier
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EC number: 203-192-6 | CAS number: 104-29-0
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Absorption by oral and dermal route, low bioaccumulation potential and fast excretion by urine.
Key value for chemical safety assessment
Additional information
Absorption
Based on its low molecular weight (202.63), solubility in water (5.471 g/l at T= 20°C) and log Kow between -1 and 4 (1.23) Chlorphenesin is expected to be absorbed by gastrointestinal tract and by dermal route. The easily absorption of Chlorphenesin by oral route, by intraperitoneal injection and by skin is confirmed in the metabolism studies available on the substance. Respiratory absorption is unlikely.
Distribution
Based on its water solubility and Log Kow=1.23 there is no concern regarding potential bioaccumulation of the substance ( threshold value for bioaccumulation alert is 4).
Metabolism
According to the QSAR prediction confirmed by in vivo metabolism studies on rats and dogs, the substance is mostly transformed in oxidation products (i.e. 3-p-chlorophenoxylactic acid and p-chlorophenoxyacetic acid) or other products of conjugate reaction on both chlorphenol and chlorphenesin.
Excretion
Due to the high water solubility of the substance after oral and dermal absorption Chlorphenesin is rapidly excreted in the urine.
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