Registration Dossier
Registration Dossier
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EC number: 203-192-6 | CAS number: 104-29-0
Endpoint summary
Administrative data
Description of key information
Chlorphenesin is a mild eye irritant and it is classified as skin irritant on precautionary manner.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation/corrosion
Chlorphenesin was tested in 2014 for its skin irritation potential with an in vitro test according to OECD TG 439 EPISKINTM reconstructed human epidermis model. No classification for skin irritation should be required based on this in vitro test. Due to minor concern on epidemiological data, classification H315 (skin irr., cat.2) is assigned as precautionary measure.
Eye irritation
Two in vitro studies are available regarding eye irritation of Chlorphenesin:
- OECD TG 437- BCOP method: IVIS test item: 25.2.
- OECD TG 492- EpiOcularTM Eye Irritation Test: Viability measured after application of test item: 2.40%
Chlorphenesin is classiifed H319 (eye irritant category 2). The eye irritation potential (but not serious eye damage concern) is confirmed also by an in vivo study performed before the implementation of the Regulation (EC n.1223/2009).
Justification for classification or non-classification
Chlorphenesin is classified H319 (eye irr. cat.2) and as precautionary manner H315 (skin irr. cat.2) according to the CLP Regulation (EC.n.1272/2008). For justification see the results of available studies.
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