Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1979
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979
Report date:
1979

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Remarks:
Pre-GLP
Test type:
standard acute method
Limit test:
yes

Test material

1
Chemical structure
Reference substance name:
[2-(1-propoxyethoxy)ethyl]benzene
EC Number:
231-327-9
EC Name:
[2-(1-propoxyethoxy)ethyl]benzene
Cas Number:
7493-57-4
Molecular formula:
C13H20O2
IUPAC Name:
[2-(1-propoxyethoxy)ethyl]benzene

Test animals

Species:
rat
Strain:
Wistar
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
10
Control animals:
no
Details on study design:
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Effect levels
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
0/10
Clinical signs:
other: Isolated instances of respiratory noise, lethargy piloerection, ataxia, chromorhinorrhea and chromodacryorrhea.
Gross pathology:
Nothing was found, all animals were normal.

Applicant's summary and conclusion

Interpretation of results:
other: not classified
Remarks:
based on CLP criteria (EC 1272/2008 and its updates)
Conclusions:
The acute oral LD50 for rats was greater than 5000 mg/kg bw.
Executive summary:

An acute oral toxicity study was performed according to a method similar to OECD 401. In this study, 10 rats were administered with Hyacinth body #3 at dose level of 5000 mg/kg bw. The mortality rates of the rats were 0/10. Clinical signs observed were isolated instances of respiratory noise, lethargy piloerection, ataxia, chromorhinorrhea and chromodacryorrhea. No lesions were found in animals necropsied at termination. The acute oral LD50 for rats was greater than 5000 mg/kg bw.