Registration Dossier
Registration Dossier
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EC number: 605-718-3 | CAS number: 174350-05-1
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Resorption
In an acute toxicity study in rats (limit test) no signs of systemic toxicity were observed after oral administration of the test substance.
In a subacute 28-day toxicity study in rats a number of clinical symptoms was observed after daily oral administration of 50, 150 or 450 mg/kg/d bw of the test substance. Moreover, reduced body weights and body weight gain, reduced food and increased water consumption were noted in the high and partially in the mid dose groups. Histopathology showed minimal degenerative lesions - single cell necrosis of tubular epithelial cells in the cortex in males of the high dose.
Based on the findings of this subacute toxicity study it can be concluded that the compound is absorbed after oral administration. Given a logPOW of 5.7, exposure via the skin cannot be excluded. Exposure via inhalation is considered negligible as the vapour pressure of the test substance is low (0.00027 Pa at 25°C).
Distribution
The solubility of the test substance in water is very low (<0.0001 g/L) and, therefore, distribution of the substance will be restricted within the organism. Considering a log POW of 5.7 the substance may potentially accumulate in lipophilic tissues.
Excretion
Information on the excretion of the substance is not available. As the effects observed in the subacute toxicity study were fully reversible within the 14-day treatment free recovery period, excretion of the substance can be assumed. Based on the molecular weight of the test substance, excretion via the kidneys is considered to be the main route of elimination. As the test substance has a low water solubility it can be assumed that the substance is metabolized (Phase I and II) prior excretion. Based on the low vapour pressure, excretion via exhalation is not assumed.
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