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EC number: 485-270-1
CAS number: -
A sub-acute repeated dose study is available performed according to OECD/EC guidelines and GLP principles. Based on gastrointestinal effects observed in the mid and high dose groups, the NOAEL was concluded to be 150 mg/kg bw/day.
The recovery rate obtained for analysis of the formulations were low and the analytical method was concluded not to be applicable.
Table 1: Mean weight gain (Day 0-27)
Absolute weight gain (g)
Relative weight gain (%)
* Significant (p<0.05)
Historical control range: weight gain of 90-100 g for males and 40-55 g for females
Table 2: Small intestinal changes at sacrifice
Number of animals
Dose group (mg/kg bw/day)
Jejunum: lacteal distension
Ileum: lacteal distension
Based on the available data, the test substance is not classified as
STOT RE according to Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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