Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 485-270-1
CAS number: -
An Ames study is available performed according to OECD/EC guidelines and GLP principles. The results showed that the substance was positive without metabolic activation in tester strain TA100.
In addition, an in vitro chromosome aberration test is available performed in Chinese Hamster V79 cells according to OECD/EC guidelines and GLP principles. The results do not indicate that the test item is clastogenic.
An in vivo Micronucleus study is available, which shows that the substance is not clastogenic in vivo. As the substance was tested positive in an AMES study, a test proposal for an in vivo COMET assay is included.
Results pre-experiment to find MTD:
Two males died within 72 hours after application of the test item. They showed toxic symptoms as reduction of spontaneous activity, rough fur, constricted opistosoma, palpebral closure and loss of weight.
All other animals survived.
The females and three males did not show signs of toxicity.
One male mouse showed toxic symptoms including reduction of spontaneous activity, rough fur, constricted opisthosoma, palpebral closure and loss of weight.
Based on the available data, the test substance is not classified as a mutagen according to Regulation (EC) No 1272/2008, however it is proposed to conduct an in vivo study to clarify this endpoint.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again