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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from authoritative database

Data source

Reference
Reference Type:
other: authoritative database
Title:
Skin irritation study of Benzenesulphonohydrazide (CAS No: 80-17-1)
Author:
IFA GESTIS
Year:
2017
Bibliographic source:
IFA GESTIS, GESTIS SUBSTANCE Database, 2017.

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
An eye irritation study was carried out in rabbits to assess the eye irritation potential of chemical Benzenesulphonohydrazide (CAS No: 80-17-1).
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzenesulphonohydrazide
Cas Number:
80-17-1
Molecular formula:
C6H8N2O2S
IUPAC Name:
Benzenesulphonohydrazide
Test material form:
solid
Details on test material:
- Name of test material (as cited in study report):Benzenesulphonohydrazide
- Molecular formula :C6H8N2O2S
- Molecular weight :172.2072 g/mol
- Substance type:Organic
- Physical state:Powder
-Smiles: c1cc(S(=O)(=O)NN)ccc1
-InChI: 1S/C6H8N2O2S/c7-8-11(9,10)6-4-2-1-3-5-6/h1-5,8H,7H2
Specific details on test material used for the study:
- Name of test material (as cited in study report):Benzenesulphonohydrazide
- Molecular formula :C6H8N2O2S
- Molecular weight :172.2072 g/mol
- Substance type:Organic
- Physical state:Powder
-Smiles: c1cc(S(=O)(=O)NN)ccc1
-InChI: 1S/C6H8N2O2S/c7-8-11(9,10)6-4-2-1-3-5-6/h1-5,8H,7H2

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
Not data available

Test system

Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
500 mg
Duration of treatment / exposure:
7 days
Observation period (in vivo):
7 days
Duration of post- treatment incubation (in vitro):
No data available
Number of animals or in vitro replicates:
No data available
Details on study design:
- Area of exposure: conjunctival sac

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
7 d
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No eye irritation was observed in treated rabbits.

Applicant's summary and conclusion

Interpretation of results:
other: Not irritating
Conclusions:
The test material Benzenesulphonohydrazide (CAS No: 80-17-1) was considered to be not irritating to the eye of rabbits.

Executive summary:

An eye irritation study was carried out in rabbits to assess the eye irritation potential of chemical Benzenesulphonohydrazide (CAS No: 80-17-1).

 

When 500 mg ofBenzenesulphonohydrazidechemical was installed into the conjunctival sac of each rabbit, no irritaton was observed in treated rabbits within 7 days.

 

Therefore the chemicalBenzenesulphonohydrazide (CAS No: 80-17-1) was considered to be not irritating to the eye of rabbits.