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EC number: 220-051-4 | CAS number: 2618-96-4
Endpoint summary
Administrative data
Description of key information
Biodegradation in water
Biodegradability of N-(benzenesulfonyl)benzenesulfonamide (CAS no. 2618 -96 -4) is predicted using QSAR toolbox version 3.4 (2017) with logKow as the primary descriptor. Test substance undergoes 0.83% degradation by BOD in 28 days. Thus, based on percentage degradation, the test chemical N-(benzenesulfonyl)benzenesulfonamide was estimated to be not readily biodegradable in water.
Biodegradation in water and sediment
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound N-(benzenesulfonyl)benzenesulfonamide (CAS No. 2618 -96 -4). If released in to the environment, 13.8% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of N-(benzene sulfonyl)benzenesulfonamide in water is estimated to be 37.5 days (900 hrs). The half-life (37.5 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of N-(benzenesulfonyl)benzenesulfonamide in sediment is estimated to be 337.5 days (8100 hrs). However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.344%), indicates that N-(benzenesulfonyl)benzenesulfonamide is not persistent in sediment.
Biodegradation in soil
The half-life period of N-(benzenesulfonyl)benzenesulfonamide (CAS No. 2618 -96 -4) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 85.4% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of N-(benzenesulfonyl) benzenesulfonamide in soil is estimated to be 75 days (1800 hrs). Based on this half-life value of N-(benzenesulfonyl)benzenesulfonamide, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
Additional information
Biodegradation in water
Various predicted data for the target compound N-(benzenesulfonyl)benzenesulfonamide (CAS No. 2618-96-4) and supporting weight of evidence studies for its structurally similar read across substance were reviewed for the biodegradation end point which are summarized as below:
In a prediction done by SSS (2017) using OECD QSAR toolbox version 3.4 with logKow as the primary descriptor, percentage biodegradability of test chemical N-(benzenesulfonyl)benzene sulfonamide(CAS No. 2618 -96 -4) was estimated.Test substance undergoes 0.83% degradation by BOD in 28 days. Thus, based on percentage degradation, the test chemical N-(benzene sulfonyl)benzenesulfonamidewas estimated to be not readily biodegradable in water.
In another prediction using the Estimation Programs Interface Suite (EPI suite, 2017), the biodegradation potential of the test compoundN-(benzenesulfonyl)benzenesulfonamide(CAS No. 2618-96-4) in the presence of mixed populations of environmental microorganisms was estimated.The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemicalN-(benzenesulfonyl)benzenesulfonamideis expected to be not readily biodegradable.
In a supporting weight of evidence study from authoritative database (J-CHECK, 2017 and EnviChem, 2014) for the read across chemical 3 -nitro-N-phenyl-4 -(phenylamino)benzene-1 -sulfonamide (CAS no. 5124 -25 -4), biodegradation experiment was conducted for 28 days for evaluating the percentage biodegradability of read across substance 3-nitro-N-phenyl-4-(phenylamino)benzene-1-sulfonamide. The study was performed according to OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I)). Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of substance 3 -nitro-N-phenyl-4 -(phenylamino)benzene-1 -sulfonamide was determined to be 0 and 5% by BOD and UV-Vis parameter in 28 days. Thus, based on percentage degradation, 3 -nitro-N-phenyl-4 -(phenylamino)benzene-1 -sulfonamide is considered to be not readily biodegradable in nature.
For the read across chemical N-Butyl-benzenesulfonamide (CAS no. 3622-84-2), biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of read across substance N-Butyl-benzenesulfonamide (J-CHECK, 2017). Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of substance N-Butyl-benzenesulfonamide was determined to be 0 and 1% by BOD, TOC removal and HPLC parameter in 28 days. Thus, based on percentage degradation, N-Butyl-benzenesulfonamide is considered to be not readily biodegradable in nature.
Another biodegradation study from secondary source (HPVIS, 2017) was conducted for 28 days for evaluating the percentage biodegradability of read across substance N-Butyl-benzene sulfonamide (CAS no. 3622 -84 -2). The study was performed according to OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test).Activated sludge was used as a test inoculum obtained from sewage treatment plant, Netherlands. Concentrated sludge (6.5 g solids/L) was left to settle for 30 min; the decanted liquid was used as inoculum (7.65 ml/L mineral medium). Initial test substance conc. used for the study were21.75 & 21.8 mg/l based on test material and 45.0 & 45.2 mg/l based on CO2 mg/l, respectively. OECD mineral medium was used as a test medium for the study. Study was performed using brown glass bottles of 2l volume at a temperature of 20-23°C. Sampling was done on day 1, 4, 6, 8, 11, 14, 18, 22, 26 and 28, respectively. Sodium acetate (40.2 mg/l) was used as a reference substance for the study. 10-day window criteria was not reached. ThCO2 was determined to be 2.07 mg CO2/mg test substance. The percentage degradation of substance N-Butyl-benzenesulfonamide was determined to be 12 and 23% at 21.8 and 21.75 mg/l conc. by CO2 evolution parameter in 28 days. Thus, based on percentage degradation, N-Butyl-benzenesulfonamide is considered to be not readily biodegradable in nature.
In a supporting weight of evidence study for the same read across chemical N-Butyl-benzenesulfonamide (CAS no. 3622-84-2),biodegradation experiment was conducted for 28 days for evaluating the percentage biodegradability of read across substance N-Butyl-benzenesulfonamide (HPVIS, 2017). The study was performed according to OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test). Activated sludge was used as a test inoculum. Initial test substance conc. used for the study was21.5 mg/l, respectively. The percentage degradation of substance N-Butyl-benzenesulfonamide was determined to be 18% by CO2 evolution parameter in 28 days. Thus, based on percentage degradation, N-Butyl-benzenesulfonamide is considered to be not readily biodegradable in nature.
On the basis of above results for target chemicalN-(benzenesulfonyl)benzenesulfonamide(from OECD QSAR toolbox version 3.4 and EPI suite, 2017) and for its read across substance (from authoritative database J-CHECK & EnviChem and secondary source HPVIS), it can be concluded that the test substanceN-(benzenesulfonyl)benzenesulfonamidecan be expected to be not readily biodegradable in nature.
Biodegradation in water and sediment
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound N-(benzenesulfonyl)benzenesulfonamide (CAS No. 2618 -96 -4). If released in to the environment, 13.8% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of N-(benzene sulfonyl)benzenesulfonamide in water is estimated to be 37.5 days (900 hrs). The half-life (37.5 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of N-(benzenesulfonyl)benzenesulfonamide in sediment is estimated to be 337.5 days (8100 hrs). However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.344%), indicates that N-(benzenesulfonyl)benzenesulfonamide is not persistent in sediment.
Biodegradation in soil
The half-life period of N-(benzenesulfonyl)benzenesulfonamide (CAS No. 2618 -96 -4) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 85.4% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of N-(benzenesulfonyl) benzenesulfonamide in soil is estimated to be 75 days (1800 hrs). Based on this half-life value of N-(benzenesulfonyl)benzenesulfonamide, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
On the basis of available information, the test substance N-(benzenesulfonyl)benzenesulfonamide can be considered to be not readily biodegradable in nature.
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