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EC number: 203-942-2 | CAS number: 112-17-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15.05 - 23.05.2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Decyl acetate
- EC Number:
- 203-942-2
- EC Name:
- Decyl acetate
- Cas Number:
- 112-17-4
- Molecular formula:
- C12H24O2
- IUPAC Name:
- decyl acetate
- Test material form:
- liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: SPF albino rabbits of the stock Chbb:HM(SPF) - Littlerussian
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.8 - 3.0 kg b.w.
- Housing: individually in PPO cages (floor area: 2576 sq.cm) with perforated floor.
- Diet: pelleted complete rabbit diet "Altromin 2123", ad libitum
- Water: ad libitum, domestic quality drinking water acidified with hydrochloric acid to pH 2.5 to prevent microbial growth
- Acclimation period: 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20°C ± 3°C
- Humidity (%): 55% + 15%
- Air changes (per hr): 10 times/hour
- Photoperiod (hrs dark / hrs light): Light was on from 6 a.m. to 6 p.m..
Test system
- Vehicle:
- not specified
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL of undiluted test item - Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 4
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): 20 ml 0.9% sodium chloride solution
- Time after start of exposure: 24 hours
SCORING SYSTEM: See 'Any other information on materials and methods'
TOOL USED TO ASSESS SCORE: fluorescein
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.9
- Reversibility:
- fully reversible within: 7 days
- Irritant / corrosive response data:
- Animals 1 and 4 showed markedly deepened folds, congestion, swelling, moderate circumcorneal injection, reaction to light, some injection of conjunctival vessels and discharge different from normal 1 hour after application. Animal 2 showed a diffuse, crimson red conjunctiva with individual vessels not easily discernible as well as obvious swelling with partial eversion of lids. Animal 3 showed some conjunctival vessels definitely injected, swelling with partial eversion of lids and discharge different from normal.
24 hours after application animals 1 and 2 showed some conjunctival vessels definitely injected and swelling above normal. Animals 3 and 4 showed diffuse, crimson red conjunctiva with individual vessels not easily discernible as well as obvious swelling with partial eversion of lids.
48 hours after application all animal showed some injected conjunctival vessels and animals 2, 3 and 4 showed additionally swelling above normal.
72 hours after application animals 3 and 4 showed some injected conjunctival vessels and swelling above normal. Animals 1 and 2 were free of any signs of eye irritation.
7 days after application all animals were free of any signs of eye irritation.
Any other information on results incl. tables
Individual irritation scores
Animal n° |
Cornea opacity |
Iris lesion |
Redness of conjunctiva |
Oedema of conjunctiva |
1 |
0.00 |
0.00 |
0.67 |
0.33 |
2 |
0.00 |
0.00 |
0.67 |
0.67 |
3 |
0.00 |
0.00 |
1.33 |
1.33 |
4 |
0.00 |
0.00 |
1.33 |
1.33 |
Mean values |
0.00 |
0.00 |
1.0 |
0.9 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test item shall not be classified as eye irritating.
- Executive summary:
The objective of this study was to assess the potential eye irritant effect of the test substance according to the method in the OECD Guideline 405 and EEC Guideline B.5.
The study was initiated with one rabbit. Since no marked eye irritation was seen in this animal three other rabbits were included in the study with time difference.
The female albino rabbits were exposed to 0.1 ml of the test article in the left eye while the right eye served as control. The eyes were examined and the changes were graded according to a numerical scale 1, 24, 48 and 72 hours as well as 7 days after dosing.
Slight to well-defined signs of irritation were observed in the treated eyes, however, all effects were fully reversible within 7 days.
The following mean values for all animals, based an the results from the 24, 48 and 72 hour readings, were calculated:
- cornea opacity score: 0.0
- iris score: 0.0
- conjunctivae score: 1.0
- chemosis score: 0.9
According to the CLP regulation, the test item shall not be classified as eye irritating.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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