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EC number: 203-942-2 | CAS number: 112-17-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
- Principles of method if other than guideline:
- The test item was applied once to the intact skin under semi-occlusive patches for 4 hours. After removal of the patches and wiping the treated areas the skin was examined for irritation. Further assessments were made 24, 48 and 72 hours after treatment.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Decyl acetate
- EC Number:
- 203-942-2
- EC Name:
- Decyl acetate
- Cas Number:
- 112-17-4
- Molecular formula:
- C12H24O2
- IUPAC Name:
- decyl acetate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 9-12 weeks
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent positive control
- yes, concurrent negative control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL
- Concentration (if solution): undiluted
POSITIVE & NEGATIVE CONTROL
- Amount(s) applied (volume or weight): 0.5 mL for solutions or 0.2 g for solids
- Concentration (if solution): undiluted - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 72 hours
- Number of animals:
- 8
- Details on study design:
- TEST SITE
- Area of exposure: 3 x 3 cm
- % coverage: 100%
- Type of wrap if used: canvas body sleeve
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes
- Time after start of exposure: 4 hours
OBSERVATION TIME POINTS: 24, 48 and 72 hours
SCORING SYSTEM:
- Method of calculation: 8-point anchored ordinate scale ranging from 'a' (very slight) to 'h' (severe). At the end of the test the reaction grades are converted to numerical scores to calculate the total irritation score per site.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.83
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 2.04
Any other information on results incl. tables
Individual skin irritation scores
8-point anchored ordinate scale:
Rabbit N° | 24 hours | 48 hours | 72 hours | |||
erythema | oedema | erythema | oedema | erythema | oedema | |
1 | d | e | d | d | b | c |
2 | c | c | c | c | a | b |
3 | d | c | d | d | d | c |
4 | d | d | d | d | d | d |
5 | d | d | c | c | b | c |
6 | c | c | d | c | b | b |
7 | c | e | c | d | c | d |
8 | d | e | d | d | c | d |
a | very slight |
b | slight |
c | fairly distinct |
d | quite distinct |
e | becoming well developed |
f | well developed |
g | becoming severe |
h | severe |
Numerical scores to calculate the total irritation score:
Rabbit N° | 24 hours | 48 hours | 72 hours | Average | ||||
erythema | oedema | erythema | oedema | erythema | oedema | erythema | oedema | |
1 | 2 | 3 | 2 | 2 | 1 | 2 | 1,67 | 2,33 |
2 | 2 | 2 | 2 | 2 | 1 | 1 | 1,67 | 1,67 |
3 | 2 | 2 | 2 | 2 | 2 | 2 | 2,00 | 2,00 |
4 | 2 | 2 | 2 | 2 | 2 | 2 | 2,00 | 2,00 |
5 | 2 | 2 | 2 | 2 | 1 | 2 | 1,67 | 2,00 |
6 | 2 | 2 | 2 | 2 | 1 | 1 | 1,67 | 1,67 |
7 | 2 | 3 | 2 | 2 | 2 | 2 | 2,00 | 2,33 |
8 | 2 | 3 | 2 | 2 | 2 | 2 | 2,00 | 2,33 |
Average | 1,83 | 2,04 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The substance is not skin irritant.
- Executive summary:
In the current study the irritation effects of the test substance were investigated in rabbits. The study was not according to an OECD TG, however, it is similar to OECD 404.
The test item was applied undiluted to the clipped and intact skin under semi-occlusive patches for 4 hours. After removal of the patches and wiping the treated areas irritation reactions were examined immediately. Further assessments were made 24, 48 and 72 hours after treatment. Positive (Geranial and cyclamen aldehyde) and negative controls (diethyl phthalate) were tested in parallel.
The reaction grades for each treatment group were converted to corresponding numerical scores that were used to calculate the total irritation score per animal.
Under the conditions of this study, the undiluted test material produced a moderately irritating effect to rabbit skin, which was still visible after 72 hours treatment. The positive controls, geraniol and cyclamen aldehyde, produced reactions much more severe and the control diethyl phthalate showed no visible signs after 72 hours.
According to the classification criteria as stipulated in CLP, a classification as a skin irritant is required in case the mean erythema or oedema score over 24, 48 and 72 hours is at or above 2.3 in at least 2 out of 3 animals. The individual scores reported in this study indicates that all erythema scores are < 2.3. Out of 8 animals, 3 rabbits have an oedema score of 2.33. All other animals (5 out of 8) have an oedema score < 2.3. From these observations it can be concluded that the test item does not require classification as a skin irritant in accordance with the CLP regulation.
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