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EC number: 226-237-1 | CAS number: 5332-24-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Bioaccumulation: aquatic / sediment:
BCFBAF model (v3.01) of Estimation Programs Interface (EPI Suite, 2017) was used to predict the bioconcentration factor (BCF) of test chemical 3-bromoquinoline ( cas No. 5332 -24 -1). The bioconcentration factor (BCF) of 3-bromoquinoline was estimated to be 46.37 L/kg whole body w.w (at 25 deg C) which does not exceed the bio concentration threshold of 2000, indicating that the chemical 3-bromoquinoline is expected to non bioaccumulate in the food chain.
Additional information
Bioaccumulation: aquatic / sediment:
BCFBAF model (v3.01) of Estimation Programs Interface (EPI Suite, 2017) was used to predict the bioconcentration factor (BCF) of test chemical 3-bromoquinoline ( cas No. 5332 -24 -1). The bioconcentration factor (BCF) of 3-bromoquinoline was estimated to be 46.37 L/kg whole body w.w (at 25 deg C) which does not exceed the bio concentration threshold of 2000, indicating that the chemical 3-bromoquinoline is expected to non bioaccumulate in the food chain.
Similarly using Bio-concentration Factor (v12.1.0.50374) module (ACD (Advanced Chemistry Development)/I-Lab predictive module) Bio-concentration Factor over the entire pH scale of the test substance 3-bromoquinoline estimated to be 11.5, 83.4, 270, 349, 360, and 361 at pH range from 1, 2, 3, 4, and 5-14 respectively. This value indicates that the test substance 3-bromoquinoline was consider to be non-accumulative in aquatic organisms.
Bioconcentration Factor (BCF) of test chemical 3-bromoquinoline (CAS no. 5332 -24 -1) was estimated using Chemspider database. The bioconcentration factor of test substance 3-bromoquino- line was estimated to be 97.57 and 97.67 at pH 5.5 and 7.4, respectively, which does not exceed the bioconcentration threshold of 2000, indicating that the chemical 3-bromoquinoline is not expected to bioaccumulate in the food chain.
In another predicted report from SciFinder database (American Chemical Society (ACS), 2017) was used for predicting the bioconcentration factor (BCF) of test chemical 3-bromoquinoline (CAS No. 5332 -24 -1). The bioconcentration factor (BCF) of 3-bromoquinoline was estimated to be 1, 6.06, 19.7, 25.4, 26.2 and 26.3 at pH range 1, 2, 3, 4, 5 and 6-10, respectively, (at 25 deg C) which does not exceed the bio concentration threshold of 2000, indicating that the chemical 3-bromoquinoline is not expected to bioaccumulate in the food chain.
From CompTox Chemistry Dashboard using OPERA (OPEn (quantitative) structure-activity Relationship Application) V1.02 model in which calculation based on PaDEL descriptors (calculate molecular descriptors and fingerprints of chemical) the bioaccumulation i.e BCF for test substance 3-bromoquinoline was estimated to be 14.1 dimensionless. The predicted BCF result based on the 5 OECD principles. Thus based on the result it is concluded that the test substance 3-bromoquinoline is non-bioaccumulative in nature.
In a supporting weight of evidence study from authoritative database (J-check, 2017) for the read across chemical 1-Azanaphthalene-8-ol (CAS no 148-24-3) Bioaccumulation experiment was conducted. Bioaccumulation test was conducted for 6 weeks for determination the bioconcentration factor (BCF) of substance 1-Azanaphthalene-8-ol (CAS no 148-24-3) on test organism Cyprinus carpio. Recovery ratio : Test water : 1st concentration area : 97.2 %, 2nd concentration area : 99.0 %, Fish : 73.6 %, - Limit of detection : Test water : 1st Concentration area: 0.0044 mg/L, 2nd concentration area: 0.00044 mg/L, Fish: 0.19 microg/g. 2 Nominal concentrations was used in the study, 1st Concentration area: 0.05 mg/L, 2nd Concentration area: 0.005 mg/L. Dimethyl sulfoxide was used as a vehicle with different concentrations in both nominal test concentrations. The bioconcentration factor (BCF) for substance 1-Azanaphthalene-8-ol was determined according static fish test. The BCF value was observed to be ≤ 4.2 L/kg at dose concentration 0.05 mg/L and ≤ 41 L/kg at dose concentration 0.005 mg/L on test organism Cyprinus carpio during 6 weeks period. Therefore it is concluded that this test chemical is nonbioaccumulative in fish and food chain.
On the basis of available information, the test 3-bromoquinoline (CAS No. 5332 -24 -1) can be considered to be nonbioaccumulative in nature.
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