3-bromoquinoline

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from authoritative database.

Data source

Reference

Reference 1

Reference Type:

other: authoritative database

Title:

Acute oral toxicity study of 2-chloro-4,6-bis(isopropylamino)-1,3,5-triazine (CAS no: 139-40-2) in rat.

Author:

U.S. National Library of Medicine

Year:

2017

Bibliographic source:

ChemIDplus, A TOXNET DATABASE, Lite Browse Advanced, 2017.

Reference 2

Reference Type:

secondary source

Title:

Acute oral toxicity study of 2-chloro-4,6-bis(isopropylamino)-1,3,5-triazine (CAS no: 139-40-2) in rat.

Author:

RTECS

Year:

2017

Bibliographic source:

RTECS (registry of toxic effect of chemical substance database), 2017.

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: as metioned below

Principles of method if other than guideline:

Acute oral toxicity of 2-chloro-4,6-bis(isopropylamino)-1,3,5-triazine (CAS no: 139-40-2)in Rat.

GLP compliance:

not specified

Test type:

other: not specified

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Propazine

EC Number:

205-359-9

EC Name:

Propazine

Cas Number:

139-40-2

Molecular formula:

C9H16ClN5

IUPAC Name:

2-chloro-4,6-bis(isopropylamino)-1,3,5-triazine

Details on test material:

- IUPAC Name: 2-chloro-4,6-bis(isopropylamino)-1,3,5-triazine
- Common Name: Propazine
- Mol. formula: C9H16ClN5
- Molecular Weight: 229.713 g/mole
- Smiles: c1(nc(nc(n1)Cl)NC(C)C)NC(C)C
- InChI: 1S/C9H16ClN5/c1-5(2)11-8-13-7(10)14-9(15-8)12-6(3)4/h5-6H,1-4H3,(H2,11,12,13,14,15)

Specific details on test material used for the study:

- IUPAC Name: 2-chloro-4,6-bis(isopropylamino)-1,3,5-triazine
- Common Name: Propazine
- Mol. formula: C9H16ClN5
- Molecular Weight: 229.713 g/mole
- Smiles: c1(nc(nc(n1)Cl)NC(C)C)NC(C)C
- InChI: 1S/C9H16ClN5/c1-5(2)11-8-13-7(10)14-9(15-8)12-6(3)4/h5-6H,1-4H3,(H2,11,12,13,14,15)

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

not specified

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

not specified

Details on oral exposure:

not specified

Doses:

3840 mg/kg bw

No. of animals per sex per dose:

not specified

Control animals:

not specified

Details on study design:

not specified

Statistics:

not specified

Results and discussion

Preliminary study:

not specified

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

3 840 mg/kg bw

Based on:

test mat.

Remarks on result:

other: 50% mortality was observed.

Mortality:

50% mortality was observed at 3840 mg/kg bw

Clinical signs:

other: not specified

Gross pathology:

not specified

Other findings:

not specified

Applicant's summary and conclusion

Interpretation of results:

Category 5 based on GHS criteria

Conclusions:

LD50 was considered to be 3840 mg/kg bw, when rat was treated with 2-chloro-4,6-bis(isopropylamino)-1,3,5-triazine orally.

Executive summary:

The acute oral toxicity study was conducted by using 2-chloro-4,6-bis(isopropylamino)-1,3,5-triazinein rat in the concentration of 3840 mg/kg bw orally. 50% mortality was observed at 3840 mg/kg bw. Therefore, LD50 was considered to be 3840 mg/kg bw, when rat was treated with 2-chloro-4,6-bis(isopropylamino)-1,3,5-triazine orally.