Registration Dossier
Registration Dossier
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EC number: 300-530-5 | CAS number: 93941-80-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- data is from safety assessment reports
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Fiber Reactive Dyes Toxicological Profiles December 1981
- Author:
- U.S. Consumer Product Safety Commission
- Year:
- 1 981
- Bibliographic source:
- Fiber Reactive Dyes Toxicological Profiles December 1981,PB83-168732
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To assess the skin irritation potential of Reactive deep green KE-4BD in rabbits
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Reactive deep green KE-4BD
- EC Number:
- 612-760-6
- Cas Number:
- 61931-49-5
- Molecular formula:
- C40H29Cl2N15O19S6.6Na•
- IUPAC Name:
- Reactive deep green KE-4BD
- Test material form:
- solid
- Details on test material:
- Name of the test chemical: Reactive deep green KE-4BD
Molecular Formula: C40H23Cl2N15Na6O19S6
Molecular Weight: 1418.909 g/mol
SMILES notation: C1=CC(=CC(=C1)S(=O)(=O)[O-])NC2=NC(=NC(=N2)Cl)NC3=CC(=C(C=C3)NN=C4C(=CC5=CC(=C(C(=C5C4=O)N)N=NC6=C(C=C(C=C6)NC7=NC(=NC(=N7)NC8=CC(=CC=C8)S(=O)(=O)[O-])Cl)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
Substance Type: Organic
Physical State: Solid
Constituent 1
- Specific details on test material used for the study:
- Name of the test chemical: Reactive deep green KE-4BD
Molecular Formula: C40H23Cl2N15Na6O19S6
Molecular Weight: 1418.909 g/mol
SMILES notation: C1=CC(=CC(=C1)S(=O)(=O)[O-])NC2=NC(=NC(=N2)Cl)NC3=CC(=C(C=C3)NN=C4C(=CC5=CC(=C(C(=C5C4=O)N)N=NC6=C(C=C(C=C6)NC7=NC(=NC(=N7)NC8=CC(=CC=C8)S(=O)(=O)[O-])Cl)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
Substance Type: Organic
Physical State: Solid
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- no data available
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- no data available
- Duration of treatment / exposure:
- no data available
- Observation period:
- no data available
- Number of animals:
- no data available
- Details on study design:
- no data available
Results and discussion
In vitro
- Other effects / acceptance of results:
- no data available
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: no data available
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No irritation observed
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- No skin irritation effects were observed when Reactive deep green KE-4BD was applied to rabbit skin.
Hence, Reactive deep green KE-4BD can be considered to be not irritating to skin. - Executive summary:
The dermal irritation potential of Reactive deep green KE-4BD was assessed in rabbits.
Reactive deep green KE-4BD was applied to the skin of rabbits and observed for signs of irritation(dose, duration not mentioned).
No skin irritation effects were observed when Reactive deep green KE-4BD was applied to rabbit skin.
Hence, Reactive deep green KE-4BD can be considered to be not irritating to skin.
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