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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data from secondary source

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Acute dermal toxicity of CAS no 105-59-9
Author:
U.S .National library of medicine
Year:
2017
Bibliographic source:
ChemID plus A TOXNET DATABASE.2017
Reference Type:
secondary source
Title:
Acute dermal toxicity of CAS no 105-59-9
Author:
European Chemicals Bureau
Year:
2000
Bibliographic source:
IUCID Data set, European Chemicals Bureau, 18–FEB–2000, 58

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute dermal toxicity study of Ethanol, 2.2’-(methylimino)bis- in rabbits
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: liquid
Details on test material:
- Name of test material (as cited in study report): N-Methyldiethanolamine
- Molecular formula (if other than submission substance): C5H13NO2
- Molecular weight (if other than submission substance): 119.163 g/mol
- Substance type: Organic
- Physical state: Liquid
- SMILES: N(CCO)(CCO)C
- InChI: 1S/C5H13NO2/c1-6(2-4-7)3-5-8/h7-8H,2-5H2,1H3
Specific details on test material used for the study:
Name of test material (as cited in study report): N-Methyldiethanolamine
- Molecular formula : C5H13NO2
- Molecular weight : 119.163 g/mol
- Substance type: Organic
- Physical state: Liquid
- SMILES: N(CCO)(CCO)C
- InChI: 1S/C5H13NO2/c1-6(2-4-7)3-5-8/h7-8H,2-5H2,1H3

Test animals

Species:
rabbit
Strain:
other: New Zealand albino
Sex:
male
Details on test animals and environmental conditions:
No data available

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
No data available
Doses:
5990 mg/kg bw
No. of animals per sex per dose:
4
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
> 5 990 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality observed in treated rabbits
Mortality:
No mortality observed in treated rabbits
Clinical signs:
No data available
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
LD50 was considered to be > 5990 mg/kg bw when 4 male New Zealand albino rabbits were treated with Ethanol, 2.2’-(methylimino)bis- (MDEA) dermally
Executive summary:

In dermal toxicity study,4 male New Zealand albino rabbits were treated with Ethanol, 2.2’-(methylimino)bis- (MDEA) in the concentration of 5990 mg/kg bw dermally. No mortality observed in treated rabbits. Therefore, LD50 was considered to be > 5990 mg/kg bw when 4 male New Zealand albino rabbits were treated with Ethanol, 2.2’-(methylimino)bis- (MDEA) (105 -59 -9) by dermal application .