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EC number: 700-890-7 | CAS number: 503614-91-3
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Between 15 February and 03 March 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- - The determination was carried out using the flask method designed to be compatible with Method A6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Remarks:
- The determination was carried out using the flask method designed to be compatible with Method A6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.
- Water solubility:
- 0.011 g/L
- Temp.:
- 20 °C
- Remarks on result:
- other: pH not reported
- Details on results:
- Due to the tabular nature of this information & to retain the integrity & coherence of the original Harlan Laboratories Ltd. Study report please see section “Any other information on results incl. tables”
- Conclusions:
- Interpretation of results: slightly soluble (0.1-100 mg/L)
The water solubility of the test item has been determined to be 1.15 x 10-2 g/L of solution at 20.0 ± 0.5 °C. - Executive summary:
The determination was carried out using the flask method designed to be compatible with Method A6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.
Conclusion
The water solubility of the test item has been determined to be 1.15 x 10-2 g/L of solution at 20.0 ± 0.5 °C.
Reference
Results
Preliminary test
The preliminary estimate of water solubility was 1.7 x 10-2 g/L at 20 °C.
Definitive test
The mean peak areas relating to the standard and sample solutions are shown in the following table:
Table 3.9
Solution |
Mean PeakArea |
Standard 10.3 mg/L |
1.4598 x 106 |
Standard 10.0 mg/L |
1.4425 x 106 |
Matrix blank |
None detected |
Sample 1A |
8.3487 x 105 |
Sample 1B |
8.2671 x 105 |
Sample 2A |
8.2333 x 105 |
Sample 2B |
8.2384 x 105 |
Sample 3A |
8.1298 x 105 |
Sample 3B |
8.1857 x 105 |
The concentration (g/L) of test item in the sample solutions is shown in the following table:
Table 3.10
Sample Number |
Time Shaken at ~ 30 ºC (hours) |
Time Equilibrated at 20 ºC (hours) |
Concentration (g/L) |
Solution pH |
1 |
24 |
26 |
1.16 x 10-2 |
6.0 |
2 |
48 |
26 |
1.15 x 10-2 |
5.8 |
3 |
72 |
26 |
1.14 x 10-2 |
5.8 |
Mean concentration: 1.15
x 10-2 g/L at 20.0 ± 0.5 ºC
Range: 1.14
x 10-2 to 1.16 x 10-2g/L
Validation
The linearity of the detector response with respect to concentration was assessed over the concentration range of 0 to 20.0 mg/L. This was satisfactory with a correlation coefficient (r2) of 0.999 being obtained.
Description of key information
The water solubility of the test item has been determined to be 1.15 x 10-2 g/L of solution at 20.0 ± 0.5 °C.
Key value for chemical safety assessment
- Water solubility:
- 11.5 mg/L
- at the temperature of:
- 20 °C
Additional information
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