Registration Dossier

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
basic toxicokinetics, other
Remarks:
Theoretical assessment
Type of information:
other: Expert statement
Adequacy of study:
key study
Study period:
3 October 2019
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see "Remark"
Remarks:
Theoretical assessment taking all currrently available relevant information into account, based on the REACH Guidance: Guidance on Information Requirements and Chemical Safety Assessment, Chapter R.7c Endpoint specific guidance. Since this is a theoretical assessment, the Klimisch value cannot be 1.
GLP compliance:
no
Type:
absorption
Results:
For risk assessment purposes the factors are set at 50% for oral absorption, inhalation absorption and dermal absorption.
Conclusions:
A toxicokinetic assessment was performed based on the available data. Based on the physical/chemical properties of the substance, absorption factors for this substance are derived to be 50% (oral), 50% (inhalation) and 50% (dermal) for risk assessment purposes. The bioaccumulation potential is expected to be low.

Description of key information

A toxicokinetic assessment was performed based on the available data. Based on the physical/chemical properties of the substance, absorption factors for this substance are derived to be 50% (oral), 50% (inhalation) and 50% (dermal) for risk assessment purposes. The bioaccumulation potential is expected to be low.

Key value for chemical safety assessment

Bioaccumulation potential:
low bioaccumulation potential
Absorption rate - oral (%):
50
Absorption rate - dermal (%):
50
Absorption rate - inhalation (%):
50

Additional information