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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Between 15 February and 20 February 2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
.
Qualifier:
equivalent or similar to
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
Using the vapor pressure balance method, designed to be compatible with Method A4 Vapour Pressure of Commission Regulation (EC) No 440/2008 of 30 May 2008, Method 104 of the OECD Guidelines for Testing of Chemicals, 23 March 2006.
Deviations:
no
GLP compliance:
yes
Type of method:
effusion method: vapour pressure balance
Temp.:
25 °C
Vapour pressure:
0.001 Pa
Transition / decomposition:
no

Results

Results of the vapor pressure determination are given in the following tables and figures.

 

Table 3.1 –Run 1-Vapor Pressure Data

 

Temperature (ºC)

Temperature (K)

Reciprocal Temperature (K-1)

Mass Difference (µg)

Mass Difference (kg)

Vapor Pressure (Pa)

Log10Vp

160

433.15

0.002308669

9.18

9.180E-09

0.012744192

-1.894687698

161

434.15

0.002303351

7.61

7.610E-09

0.010564630

-1.976145722

162

435.15

0.002298058

7.54

7.540E-09

0.010467452

-1.980159033

163

436.15

0.002292789

3.38

3.380E-09

0.004692306

-2.328613678

164

437.15

0.002287544

16.33

1.633E-08

0.022670224

-1.644544194

165

438.15

0.002282323

15.93

1.593E-08

0.022114921

-1.655314603

166

439.15

0.002277126

0.39

3.900E-10

0.000541420

-3.266465772

167

440.15

0.002271953

2.59

2.590E-09

0.003595584

-2.444230615

168

441.15

0.002266803

11.77

1.177E-08

0.016339775

-1.786753916

169

442.15

0.002261676

5.18

5.180E-09

0.007191167

-2.143200619

170

443.15

0.002256572

6.44

6.440E-09

0.008940370

-2.048644511

Table 3.2 –Run 3-Vapor Pressure Data

 

Temperature (ºC)

Temperature (K)

Reciprocal Temperature (K-1)

Mass Difference (µg)

Mass Difference (kg)

Vapor Pressure (Pa)

Log10Vp

161

434.15

0.002303351

3.61

3.610E-09

0.005011605

-2.300023177

162

435.15

0.002298058

1.73

1.730E-09

0.002401683

-2.619484276

163

436.15

0.002292789

0.47

4.700E-10

0.000652480

-3.185432521

166

439.15

0.002277126

3.69

3.690E-09

0.005122665

-2.290504013

167

440.15

0.002271953

5.73

5.730E-09

0.007954708

-2.099375757

168

441.15

0.002266803

24.18

2.418E-08

0.033568035

-1.474074082

169

442.15

0.002261676

9.73

9.730E-09

0.013507733

-1.869417538

170

443.15

0.002256572

4.79

4.790E-09

0.006649747

-2.177194865

 

No statistical analysis is given due to the nature of the plot

Table 3.3 –Run 5-Vapor Pressure Data

 

Temperature (ºC)

Temperature (K)

Reciprocal Temperature (K-1)

Mass Difference (µg)

Mass Difference (kg)

Vapor Pressure (Pa)

Log10Vp

160

433.15

0.002308669

6.91

6.910E-09

0.009592850

-2.018052331

161

434.15

0.002303351

1.88

1.880E-09

0.002609922

-2.583372529

164

437.15

0.002287544

2.04

2.040E-09

0.002832043

-2.547900211

166

439.15

0.002277126

12.79

1.279E-08

0.017755797

-1.750659834

168

441.15

0.002266803

15.62

1.562E-08

0.021684562

-1.663849349

169

442.15

0.002261676

15.15

1.515E-08

0.021032081

-1.677117746

170

443.15

0.002256572

20.25

2.025E-08

0.028112188

-1.551105351

 

No statistical analysis is given due to the nature of the plot

Table 3.4 –Run 8-Vapor Pressure Data

 

Temperature (ºC)

Temperature (K)

Reciprocal Temperature (K-1)

Mass Difference (µg)

Mass Difference (kg)

Vapor Pressure (Pa)

Log10Vp

160

433.15

0.002308669

2.28

2.280E-09

0.003165224

-2.499595532

161

434.15

0.002303351

2.28

2.280E-09

0.003165224

-2.499595532

162

435.15

0.002298058

7.14

7.140E-09

0.009912149

-2.003832167

164

437.15

0.002287544

0.08

8.000E-11

0.000111060

-3.954440392

166

439.15

0.002277126

16.64

1.664E-08

0.023100583

-1.636377057

167

440.15

0.002271953

11.30

1.130E-08

0.015687295

-1.804451935

168

441.15

0.002266803

6.91

6.910E-09

0.009592850

-2.018052331

169

442.15

0.002261676

16.01

1.601E-08

0.022225982

-1.653139047

170

443.15

0.002256572

2.59

2.590E-09

0.003595584

-2.444230615

 

No statistical analysis is given due to the nature of the plot

Please see Attachment 3 for Graphs of log10 Vapor Pressure vs Reciprocal Temperature Runs 1, 3, 5 and 8.

Conclusions:
The vapor pressure of the test item has been determined to be less than 5.6 x 10-4 Pa at 25 ºC.
Executive summary:

The vapor pressure of BMS-589154-01has been determined to be less than 5.6 x 10-4 Pa at 25 °C, using the vapor pressure balance method, designed to be compatible with Method A4 Vapour Pressure of Commission Regulation (EC) No 440/2008 of 30 May 2008, Method 104 of the OECD Guidelines for Testing of Chemicals, 23 March 2006.

Conclusion

The vapor pressure of the test item has been determined to be less than 5.6 x 10-4Pa at 25 ºC.

Description of key information

The vapor pressure of the test item has been determined to be less than 5.6 x 10-4 Pa at 25 ºC.

Key value for chemical safety assessment

Vapour pressure:
0.001 Pa
at the temperature of:
25 °C

Additional information