Registration Dossier
Registration Dossier
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EC number: 201-368-7 | CAS number: 81-64-1
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Several in vitro assays (Ames tests, a chromosome aberration test, a
HGPRT assay, 2 SCE assays and several UDS/DNA repair assays) are
published. Additionally an in-vitro micronuleus test in chinese hamster
V79 cells according to OECD TG 487 was conducted.
No in vivo assay is available.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (positive)
Genetic toxicity in vivo
Description of key information
No in vivo assay is available.
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In the Ames test, 1,4-dihydroxyanthraquinoe was positive (with the exception of those assays were only a limited number of S. typhimurium strains were used. 1,4-dihydroxyanthraquinone was also positive in the CA test and the in-vitro micronucleus test in Chinese hamster V79 cells.
In the HGPRT test and the UDS/DNA repair assays, 1,4-dihydroxyanthraquinone was negative, also in the genotoxicity assay in Saccharomyces cervesia. In the SCE assay, 1,4-dihydroxyanthraquinone revealed a weak (and dose independent) effect.
In 2 in vitro DNA binding assays a positive and a negative result was obtained (see section 7.9.3 specific investigations).
Justification for classification or non-classification
In the Ames tests, the chromosome aberration test and the in-vitro MNT a positive result was obtainded. In the HGPRT test and the UDS/DNA repair assays, 1,4-dihydroxyanthraquinone was negative, also in the genotoxicity assay in Saccharomyces cervesia. In the SCE assay, 1,4-dihydroxyanthraquinone revealed a weak (and dose independent) effect.
In 2 in vitro DNA binding assays a positive and a negative result was obtained (see section 7.9.3 specific investigations).
Overall, 1,4-dihydroxyanthraquinone was positive in several in-vitro assays, but no in-vivo studies are available. Based on the inconclusive results a classification according to CLP classification criteria (Regulation (EC) No 1272/2008) is not suitable, however due to the ambigouos results 1,4-dihydroxyanthraquinone is allocated to the medium hazard band.
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