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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

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Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1981
Report date:
1981

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Proposed Guidelines of the US EPA Paragraph 163.81-5 "Primary Dermal Irritation Study", Federal register, Vol. 43, No. 163, August 22, 1978
Deviations:
not applicable
Principles of method if other than guideline:
Procedure as given in guideline cited. Scoring of skin effects according to Draize (1959).
GLP compliance:
no
Remarks:
no GLP implemented at that time

Test material

Constituent 1
Chemical structure
Reference substance name:
1-chlorooctane
EC Number:
203-915-5
EC Name:
1-chlorooctane
Cas Number:
111-85-3
Molecular formula:
C8H17Cl
IUPAC Name:
1-chlorooctane

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Kleintierfarm Madoerin AG, Fuellingsdorf, Switzerland
- Age at study initiation: 12-16 weeks
- Weight at study initiation: 2.3-3.0 kg
- Housing: individually in stainless steel cages
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 4 days


ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +/- 2°C
- Humidity (%): 55 +/- 10%
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12


IN-LIFE DATES: From: 20. August 1981 To: 01. September 1981

Test system

Type of coverage:
occlusive
Preparation of test site:
abraded
Vehicle:
unchanged (no vehicle)
Controls:
no
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL
- Concentration (if solution): undiluted
Duration of treatment / exposure:
24 hours
Observation period:
21 days
Number of animals:
6
Details on study design:
The test was conducted on intact and abraded skin.

TEST SITE
- Area of exposure: back and flank (one side was slightly scarified by making minor incisions through the stratum corneum)
- % coverage: 2.5 x 2.5 cm
- Type of wrap if used: test item applied under a patch of surgical gauze and covered with aluminium foil; then the trunk of the animals wrapped with an occlusive bandage of elastic adhesive dressing.

REMOVAL OF TEST SUBSTANCE
- Washing : not reported

OBSERVATION SCHEDULE:
- immediately; 48 and 72 hours; 4, 7, 14 and 21 days, unless the skin is normal at 7 or 14 days

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 24, 48 and 72 hours
Score:
1.72
Max. score:
4
Reversibility:
not fully reversible within: 7 days
Remarks on result:
other: intact skin
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 24, 48 and 72 hours
Score:
0.44
Max. score:
4
Reversibility:
not fully reversible within: 7 days
Remarks on result:
other: intact skin
Other effects:
No acute toxicological signs were observed in the animals during the test period. After 7 days one rabbit showed necrosis of the skin at the application area.

Any other information on results incl. tables

The test substance showed a slight skin irritation when applied to intact and abraded skin. For intact skin the mean erythema score after 24, 48 and 72 hours was 1.72/4 and the respective mean edema score 0.44/4.

Applicant's summary and conclusion

Interpretation of results:
Category 3 (mild irritant) based on GHS criteria
Remarks:
Migrated information
Conclusions:
Under the conditions of the study the test item showed a slight skin irritation potential on intact and abraded rabbit skin. For intact skin the mean erythema score after 24, 48 and 72 hours was 1.72/4 and the respective mean edema score 0.44/4.