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EC number: 630-473-4
CAS number: 14595-54-1
experimental study and two reliable QSAR results are available to assess
the aquatic toxicity of the registered substance.
assess the short-term toxicity to aquatic invertebrates, one
experimental study and one QSAR result are available on the registered
The experimental study (NOACK, 2018) was
assessed as the key study and was performed on the registered substance
according to OECD Guideline 202 with GLP statement using a passive
dosing system. The test substance was exposed to Daphnia magna at five
concentrations (at and below maximum achievable water solubility) and a
control, under static conditions for 48 hours. According to the results
of this study, the 48h-EC50 was determined at 0.682 mg/L (95% CL: 0.627
- 0.753 mg/L), based on initial measured concentrations of the test
QSAR prediction (KREATiS, 2017; Model:iSafeRat®
holistic HA-QSAR v1.7), assessed as a supporting data, was
performed on the registered substance. The immobility of the
daphnids was determined using a validated QSAR for the Mode of
Action in question, (MOA 1, non-polar narcosis), using a training
set of 58 chemicals derived from 48 -hour tests on daphnids, for
which the concentrations of the test substance had been determined
by chemical analyses over the test period. The 48h-EC50 value on
the registered substance based on mobility was determined at 1.1
mg/L (95% CL: 1.1-1.2 mg/L).This QSAR result supports
the experimental key study performed on the same substance with an
EC50 value in the same order of magnitude, considering the
biological and experimental variabilities (factor <2) . Therefore,
this QSAR is considered relevant and sufficient to assess, alone,
the toxicity of the registered substance to aquatic algae, without
the use of an experimental study.
assess the toxicity of the registered substance to aquatic algae, the
QSAR model presented above (iSafeRat
holistic approach v1.7) was used. The
growth inhibition of algae was determined using a validated QSAR for the
Mode of Action in question, (MOA 1, non-polar narcosis), using a
training set of 40 chemicals derived from 72 -hour ErC50 tests on algae,
for which the concentrations of the test substance had been determined
by chemical analyses over the test period. The 72h-ErC50 value on
the registered substance based on growth rate was determined at 0.98
mg/L (95% CL: 0.92 - 1.0 mg/L). An in vivo algae study is
not considered necessary as this QSAR is considered sufficient to cover
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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