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EC number: 630-473-4
CAS number: 14595-54-1
4.8/1: Water Solubility Results at 20 °C
Sampling of equilibrium
Calculated Concentration2 (mg/L)
Time after achieving the test temperature of 20 ± 0.5 °C
Dilution factor of 4000 and exact weight of the external standard taken
Calculation according to formula (1)
Calculation according to formula (2)
analysis for both replicates demonstrated that the slope of the
regression line of the water
solubility of six successive samples was not significantly different
slope of the concentration vs. time regression graph was statistically
not significantly different from zero (minimum of five samples).
concentration measured for each replicate sampling did not differ by
more than 30 % (minimum of five samples).
determined solubilities of the three test vessels did not differ by more
than 15 %.
were kept constant within ± 0.5 °C.
water solubility of test item was determined under
GLP according OECD 105 guideline and EU A6 guideline, flask method,
modified with slow stirring approach, as liquid with low solubility
study was conducted with double distilled water, in triplicate vessels, with
pre-incubation at 30 ±
°C for 72 h and at least 24 h incubation after reduction to test
temperature of 20 ± 0.5 °C before the first sampling. Further samplings
were performed after time intervals of at least 5 hours.
test substance was extracted with SPME, and analysed by validated GC-MS
43.2 h of incubation, five consecutive samples had a variation of less
than 15 %, showing that the equilibrium was reached.
water solubility of the test item was determined at 20 °C, pH 6 to be
Equilibrium reached after 72h incubation at 30°C + 43h equilibration at
pH of saturated solution: 6.0.
A fully reliable experimental study,
conducted according to OECD/EU method and under GLP, is available. It is
considered as a key study. The result is retained as key data.
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