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Diss Factsheets

Toxicological information

Genetic toxicity: in vivo

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Administrative data

Endpoint:
in vivo mammalian somatic cell study: cytogenicity / bone marrow chromosome aberration
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1982
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: According to basic scientific principles.
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
read-across: supporting information
Reference
Endpoint:
in vivo mammalian somatic cell study: cytogenicity / bone marrow chromosome aberration
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Study period:
1982
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: According to basic scientific principles.
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
reference to same study
Sex:
not specified
Genotoxicity:
negative
Toxicity:
no effects
Vehicle controls validity:
valid
Negative controls validity:
not applicable
Positive controls validity:
not applicable
Conclusions:
Interpretation of results: negative
Stoddard Solvent did not induce significant chromosomal abnormalities.
Executive summary:

This data is being read across from the source study that tested Stoddard solvent based on analogue read across.

Stoddard Solvent did not induce significant chromosomal abnormalities.

Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1982

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 475 (Mammalian Bone Marrow Chromosome Aberration Test)
GLP compliance:
not specified
Type of assay:
chromosome aberration assay

Test material

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
DMSO
Doses / concentrations
Remarks:
Doses / Concentrations:
0, 0.087, 0.289, 0.868 mL/kg DMSO
Basis:
nominal conc.
Control animals:
yes, concurrent vehicle

Results and discussion

Test results
Sex:
not specified
Genotoxicity:
negative
Toxicity:
no effects
Vehicle controls validity:
valid
Negative controls validity:
not applicable
Positive controls validity:
not applicable

Applicant's summary and conclusion

Conclusions:
Interpretation of results: negative
Stoddard Solvent did not induce significant chromosomal abnormalities.
Executive summary:

Stoddard Solvent did not induce significant chromosomal abnormalities.

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