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Toxicity to microorganisms

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Endpoint:
toxicity to microorganisms, other
Remarks:
Growth inhibition
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: This summary has a reliability of 2 because the results are estimated using a computer model that is appropriate for use with this hydrocarbon substance
Reason / purpose:
read-across: supporting information
Qualifier:
no guideline followed
Principles of method if other than guideline:
The aquatic toxicity was estimated by a QSAR, the Petrotox computer model (v. 3.04). This model combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (Kmw) that describe the partitioning of the hydrocarbons between the water and organism
GLP compliance:
no
Remarks:
The data were calculated by a computer model
Analytical monitoring:
not required
Vehicle:
no
Test organisms (species):
Tetrahymena pyriformis
Test type:
other: QSAR modeled data
Water media type:
freshwater
Limit test:
no
Total exposure duration:
48 h
Key result
Duration:
48 h
Dose descriptor:
other: EL50
Effect conc.:
43.98 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth inhibition
Key result
Duration:
48 h
Dose descriptor:
other: NOELR
Effect conc.:
1.116 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth inhibition
Validity criteria fulfilled:
yes
Conclusions:
The estimated protozoan, Tetrahymena pyriformis, 48-hr EL50 value for this substance is 43.98 mg/L based on growth inhibition
Executive summary:

The aquatic toxicity was estimated using the Petrotox computer model, which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism. The estimated protozoan, Tetrahymena pyriformis, 48-hr EL50 value for this substance is 43.98 mg/L based on growth inhibition.

Endpoint:
toxicity to microorganisms, other
Remarks:
Growth Inhibition
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: This summary has a reliability of 2 because the results are estimated using a computer model that is appropriate for use with this hydrocarbon substance
Reason / purpose:
read-across: supporting information
Qualifier:
no guideline followed
Principles of method if other than guideline:
The aquatic toxicity was estimated by a QSAR, the Petrotox computer model (v. 3.04). This model combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (Kmw) that describe the partitioning of the hydrocarbons between the water and organism
GLP compliance:
no
Remarks:
The data were calculated by a computer model
Analytical monitoring:
not required
Vehicle:
no
Test organisms (species):
Tetrahymena pyriformis
Test type:
other: QSAR modeled data
Water media type:
freshwater
Limit test:
no
Total exposure duration:
48 h
Key result
Duration:
48 h
Dose descriptor:
other: EL50
Effect conc.:
185.1 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth inhibition
Key result
Duration:
48 h
Dose descriptor:
other: NOELR
Effect conc.:
1.705 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth inhibition
Validity criteria fulfilled:
yes
Conclusions:
The estimated protozoan, Tetrahymena pyriformis, 48-hr EL50 value for this substance is 185.1 mg/L based on growth inhibition
Executive summary:

The aquatic toxicity was estimated using the Petrotox computer model, which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism. The estimated protozoan,Tetrahymena pyriformis, 48-hr EL50 value for this substance is 185.1 mg/L based on growth inhibition.

Description of key information

The estimated protozoan, Tetrahymena pyriformis, 48-hr EL50 value for Hydrocarbons, C9-C12, n-alkanes, isoalkanes, cyclics, aromatics (2-25%)is 43.98 mg/L based on growth inhibition.

The estimated protozoan, Tetrahymena pyriformis, 48-hr EL50 value for Hydrocarbons, C11-C14, n-alkanes, isoalkanes, cyclics, aromatics (2-25%) is 185.1 mg/L based on growth inhibition.

Key value for chemical safety assessment

Additional information

The hydrocarbons, C9-C12, n-alkanes, isoalkanes, cyclics, aromatics (2-25%), estimated protozoan, Tetrahymena pyriformis, 48-hr EL50 value is 43.98 mg/L, based on growth inhibition.

The hydrocarbons, C11-C14, n-alkanes, isoalkanes, cyclics, aromatics (2-25%), estimated protozoan,Tetrahymena pyriformis, 48-hr EL50 value is 185.1 mg/L, based on growth inhibition.