Registration Dossier

Administrative data

Description of key information

Acute Toxicity-Oral LD50> 15000 mg/kg in rats (OECD TG 401)


Acute Toxicity-Dermal LD50> 4mL/kg (~3400 mg/kg) in rabbits (OECD TG 402)


Acute Toxicity-Inhalation LC50> 13.1 mg/L (13100 mg/m3) (OECD TG 403)

Key value for chemical safety assessment

Additional information

The acute toxicity of C9-14 Aliphatics (2-25% Aromatics) has been fully evaluated.  All of the animal studies were performed in a manner similar or equivalent to currently established OECD guidelines.  Based on these data, C9-14 Aliphatics (2-25% Aromatics) have a low order of acute toxicity by the oral, dermal, and inhalation routes of exposure.

Justification for classification or non-classification

The test substance, C9-14 aliphatics (2-25% aromatics), is minimally toxic via ingestion where the LD50 is >5050 mg/kg, via dermal exposure where the LD50 is >15000 mg/kg, and by inhalation where the LC50 value >13.1 mg/L (13100 mg/m3). These findings do not warrant classification of C9 -C14 Aliphatics (2 -25% Aromatics) under the new Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures (CLP) do not warrant classification under the Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations (DSD/DPD). The test substance is classified under EU CLP guidelines as a Category 1 aspiration hazard based on its physical and chemical properties (hydrocarbon fluid, viscosity ≤ 20,5 mm2/s) and as an R65 aspiration hazard under the EU DSD/DPD.