Registration Dossier
Registration Dossier
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EC number: 903-139-3 | CAS number: -
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- A read-across justification is provided in the IUCLID chapter "assessment reports"
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VI
- Author:
- Smyth Jr. HF et al.
- Year:
- 1 962
- Bibliographic source:
- Am. Ind. Hyg. Ass. J., 23, 95-107
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- secondary source
- Year:
- 2 008
- Bibliographic source:
- RIFM database
Materials and methods
- Principles of method if other than guideline:
- acute inhalative toxicity testing using a static method
- GLP compliance:
- no
- Test type:
- other: inhalation risk test
- Limit test:
- yes
Test material
- Reference substance name:
- 2-methylbutan-1-ol
- EC Number:
- 205-289-9
- EC Name:
- 2-methylbutan-1-ol
- Cas Number:
- 137-32-6
- Molecular formula:
- C5H12O
- IUPAC Name:
- 2-methylbutan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): 2-Methylbutanol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: albino
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Source and rate of air: room air
- System of generating particulates/aerosols: The test material (50 - 100 grams) was spread over a shallow tray which was placed in a 120-liter sealed chamber for a minimum of 24 hours - Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 8 h
- Concentrations:
- concentrated vapor
- No. of animals per sex per dose:
- 6
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- ca. 10 mg/L air
- Exp. duration:
- 8 h
- Remarks on result:
- other: calculated acc. to formula: vapour saturation (mg/l) = 0.0412 * vapour pressure (hPa) * molecular weight (g/mol)
- Mortality:
- No mortality within the 14 day observation period after exposure of 8 h.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
