Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 903-139-3 | CAS number: -
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- For justification of read across please refer to section 13.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- No information
- Author:
- Gaillard D and Derache R
- Year:
- 1 965
- Bibliographic source:
- Trav Soc. Pharm . Montpellier 25, 51-62 (1965)
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- Gaillard D and Derache R
- Year:
- 1 982
- Bibliographic source:
- Patty's Ind. Hyg. Toxicol. Vol. 2c, 3rd ed., 4591-4594 (1982)
Materials and methods
- Objective of study:
- distribution
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- Pentan-1-ol
- EC Number:
- 200-752-1
- EC Name:
- Pentan-1-ol
- Cas Number:
- 71-41-0
- Molecular formula:
- C5H12O
- IUPAC Name:
- pentan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): Pentan-1-ol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Duration and frequency of treatment / exposure:
- no data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
2000 mg/kg bw
- No. of animals per sex per dose / concentration:
- no data
- Control animals:
- not specified
- Details on dosing and sampling:
- PHARMACOKINETIC STUDY (Absorption, distribution, excretion)
- Tissues and body fluids sampled: urine, blood
- Time and frequency of sampling: up to 8 h
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on excretion:
- Blood: 6.7 mg/100 mL at 15 min, 12 mg/100 mL at 30 min, 12 mg/100 mL at 1 h, 7 mg/100 mL at 1.5 h, 4.6 mg/100 mL at 2 h, 2.2 mg/100 mL at 4 h and 2 mg/100 mL at 8 h.
Urine: no alcohol detected
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
