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EC number: 217-110-1 | CAS number: 1742-95-6
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
72 hrs aquatic toxicity study was predicted to assess toxic effects of the test compound 4-Amino-1,8-naphthalimide (CAS no.1742 -95 -6) and the result were predicted (SSS QSAR Prediction model, 2016). The study was based on the effects of the test compound on Desmodesmus subcapitata in a static fresh water system. The predicted data suggests the effective concentration (EC50) for the test compound 4-Amino-1,8-naphthalimide (CAS no.1742 -95 -6) was estimated to be 222.021 mg/l on the basis of growth rate.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 222.021 mg/L
Additional information
Various predicted data for the target chemical 4-Amino-1,8-naphthalimide(CAS No. 1742-95-6) and the study of its read across substancewere reviewed to summarize the following information:
72 hrs aquatic toxicity study was predicted to assess toxic effects of the test compound 4-Amino-1,8-naphthalimide (CAS no.1742 -95 -6) and the result were predicted (SSS QSAR Prediction model, 2016). The study was based on the effects of the test compound on Desmodesmus subcapitata in a static fresh water system. The predicted data suggests the effective concentration (EC50) for the test compound 4-Amino-1,8-naphthalimide (CAS no.1742 -95 -6) was estimated to be222.021 mg/l on the basis of growth rate.
Based on the QSAR prediction done using the EPI Suite ECOSAR version 1.10, the 96 hours EC50 was estimated to be 321.762 mg/l on green algae for substance 4-Amino-1,8-naphthalimide with growth inhibition effects.
Short term toxicity to algae study was carried out for 72 hrs (J-CHECK, 2016). Based on growth rate of the test organism algae, the 72 hrs EC50 value was determined to be > 150 mg/l.
Short term toxicity toSelenastrum capricornutumstudy was carried out for 72 hrs (SIDS INITIAL ASSESSMENT PROFILE, SIAM 20, 19-21 April 2005). The test organism used for the study was Selenastrum capricornutum.The 72 hrs ExC50 value for Selenastrum capricornutum was determined to be 161 mg/l.
Based on the overall reported results for target and read across substance, it can be concluded that the substance 4-Amino-1,8-naphthalimide can be considered as non-toxic to aquatic organisms and thus cannot be classified as hazardous as per the CLP criteria.
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