Registration Dossier
Registration Dossier
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EC number: 217-110-1 | CAS number: 1742-95-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Data is from database
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Acute oral toxicity of 1-HBenz( de)isoquinoline-1,3( 2H)-dione,6-amino-
- Author:
- U.S. Government
- Year:
- 2 015
- Bibliographic source:
- RTECS (Registry of Toxic Effects of Chemical Substances);
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Acute oral toxicity of 1-HBenz( de)isoquinoline-1,3( 2H)-dione,6-amino- in rats
- GLP compliance:
- not specified
- Test type:
- other: No data
- Limit test:
- no
Test material
- Reference substance name:
- 4-aminonaphthalene-1,8-dicarboximide
- EC Number:
- 217-110-1
- EC Name:
- 4-aminonaphthalene-1,8-dicarboximide
- Cas Number:
- 1742-95-6
- Molecular formula:
- C12H8N2O2
- IUPAC Name:
- 6-amino-1H-benzo[de]isoquinoline-1,3(2H)-dione
- Reference substance name:
- 1-HBenz( de)isoquinoline-1,3( 2H)-dione,6-amino-
- IUPAC Name:
- 1-HBenz( de)isoquinoline-1,3( 2H)-dione,6-amino-
- Details on test material:
- - Name of test material (as cited in study report): 1-HBenz( de)isoquinoline-1,3( 2H)-dione,6-amino-
- Molecular formula (if other than submission substance): C12H8N2O2
- Molecular weight (if other than submission substance): 212.207 g/mole
- Substance type: Organic
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- 10000 mg/kg/day
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality observed
- Mortality:
- No mortality observed in treated rats.
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LD50 was considered to be > 10000 mg/kg/day when rats were treated with 1-HBenz( de)isoquinoline-1,3( 2H)-dione,6-amino- orally.
- Executive summary:
In acute toxicity study rats were treated with 1-HBenz ( de)isoquinoline-1,3( 2H)-dione,6-amino- in the concentration of 10000 mg/kg/day. No effect on survival of treated rats were observed at 10000 mg/kg bw. Therefore,LD50 was considered to be> 10000 mg/kg/day when rats were treated with 1-HBenz( de)isoquinoline-1,3( 2H)-dione,6-amino- orally.
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