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Administrative data

Link to relevant study record(s)

Description of key information

Short description of key information on bioaccumulation potential result: 
At low non irritating concentrations, the substance may be absorbed after oral exposure, metabolised in the liver (via the CYP), may be distributed as metabolites entering the bloodstream and finally excreted mainly in the urine.
Considering the substance low vapour pressure (no volatilisation), exposure by inhalation to the substance is unlikely to occur.
Short description of key information on absorption rate:
The substance may be dermal absorbed.

Key value for chemical safety assessment

Bioaccumulation potential:
low bioaccumulation potential

Additional information

At low non irritating concentrations, the substance may be absorbed after oral exposure, metabolised in the liver (via the CYP), may be distributed as metabolites entering the bloodstream and finally excreted mainly in the urine.

Considering the substance low vapour pressure (no volatilisation), exposure by inhalation to the substance is unlikely to occur.

As water soluble surface active liquid, the substance may be absorbed during dermal exposure.

Discussion on bioaccumulation potential result:

The substance is a corrosive liquid with a middle molecular weight of 293.49 g/mol. Moreover, it is water soluble (see § 4). Therefore, the substance is an amphiphilic substance for which the gastro-intestinal absorption may occur by the ability of the substance to dissolve into the gastro-intestinal fluids after oral exposure and hence make contact with the mucosal surface. However, this contact is limited by the corrosive properties of the substance which can induce membrane destruction according to the concentrations. However, at low non irritating concentrations, the substance may be absorbed after oral exposure, mainly undergo liver cytochrome P450 dependent N-hydroxylation. Metabolites are likely distributed throughout the tissues entering the bloodstream and then mainly excreted in the urine. Finally, acute toxicity study and 28 -day repeated dose toxicity study performed in rats with the substance administered by oral route didn't show any systemic effect at 50 mg/kg bw and 30 mg/kg bw/d respectively (see § 7.2 and § 7.5) .

The substance is a liquid with low vapour pressure inducing no significant volatilization under environmental conditions. Hence, exposure by inhalation is unlikely to occur.

Discussion on absorption rate:

The substance is a water soluble liquid at ambient temperature with corrosive properties (pH > 12). As the substance exhibits both hydrophobic and hydrophilic moities, dermal absorption may occur. In fact, considering both its middle molecular weight (293.49 g/mol) and the compound hydrophobic part, uptake into the stratum corneum itself may be rapid after skin contact at low non-irritating concentrations. Then, taking into account its water solubility, the substance partitions from the stratum into the epidermis may occur followed by diffusion into the dermis which contains blood capillaries. Following systemic absorption, the substance may be excreted by the kidney in the urine considering its water solubility.