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Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
other: literature data
Adequacy of study:
key study
Study period:
1970
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study is considered as reliable with restrictions.
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
not specified
GLP compliance:
not specified
Test type:
acute toxic class method
Limit test:
no
Species:
rat
Strain:
Wistar
Sex:
male
Details on test animals and environmental conditions:
Body weight: about 170 g
Route of administration:
oral: unspecified
Vehicle:
other: no data
No. of animals per sex per dose:
24 animals
Control animals:
not specified
Sex:
male
Dose descriptor:
LD50
Effect level:
12.9 other: g/kg
Based on:
test mat.
Mortality:
none
Clinical signs:
relaxation of the skeletal muscles, motor paralysis of the hind limbs, stimulation of the respiratory and cardiac frequencies
Body weight:
no data
Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The oral LD50 of Acetamide was determined in male rats by Hashimoto et al. Acetamide was shown to be of low toxicity. Large doses of Acetamide produced relaxation of the skeletal muscles, motor paralysis of the hind limbs and stimulation of the respiratory and cardiac frequencies.
The LD50 of Acetamide was determined as 12.9 g/kg body weight.
Executive summary:

The oral LD50 of Acetamide was determined in male rats and mice by Hashimoto et al. Acetamide was shown to be of low toxicity. Large doses of Acetamide produced relaxation of the skeletal muscles, motor paralysis of the hind limbs and stimulation of the respiratory and cardiac frequencies. The LD50 of Acetamide was determined as 12.9 g/kg body weight in the rat and in the mouse.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
12 900 mg/kg bw
Quality of whole database:
One reliable study is available.

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

The oral LD50 of Acetamide was determined in male rats and mice by Hashimoto et al. Acetamide was shown to be of low toxicity. Large doses of Acetamide produced relaxation of the skeletal muscles, motor paralysis of the hind limbs and stimulation of the respiratory and cardiac frequencies. The LD50 of Acetamide was determined as 12.9 g/kg body weight in mice and in rats.


Justification for selection of acute toxicity – oral endpoint
Study is considered as reliable with restrictions.

Justification for classification or non-classification

Based on the available data no classification is required.