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Physical & Chemical properties

Partition coefficient

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Description of key information

Study conducted according to OECD Guideline 117, data are reliable without restrictions. 

Key value for chemical safety assessment

Log Kow (Log Pow):
-2.196
at the temperature of:
25 °C

Additional information

The study was performed using a HPLC with a C18 column. Six reference items with different retention times and thiourea for the determination of the dead time were used to produce a calibration curve, since retention time on hydrophobic columns and POWare correlated. For each reference item, the capacity factor K was calculated from the retention time of thiourea and the retention time of the respective reference item.

A calibration function (log K versus log POW, linear fit) was determined using the literature values for POWof the reference items and the retention times in the six determinations.

 

The chromatogram of the test item gave one peak. With the calibration function log K versus log POW, the corresponding log POW was determined with:

- 2.196 ± 0.000 (mean ± standard deviation).

This calculated value lies below the calibrated range (0.30 – 2.70), therefore the Log POWof Acetamid is stated as< 0.3.