Registration Dossier
Registration Dossier
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EC number: 206-991-8 | CAS number: 409-21-2
Endpoint summary
Administrative data
Description of key information
No irritation or other skin changes were observed in an acute dermal toxicity study performed according to OECD testing guideline 402 (see chapter 7.3.1).
Silicon carbide is an inert chemical and is likely to cause mechanical eye irritation due to large particle size and shape. Mechanical eye irritation produced by silicon carbide would camouflage any chemical irritation that might be caused by the substance. For this reason and due to the unethical aspect of in vivo eye irritation testing of a mechanical irritant, it is not considered reasonable to perform an eye irritation study.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
