Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 235-487-0 | CAS number: 12251-53-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented publication which meets basic scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Development and Validation of an Alternative Dermal Sensitization Test: The Mouse Ear Swelling Test (MEST)
- Author:
- Gad, S.C. et al.
- Year:
- 1 986
- Bibliographic source:
- Toxicol Appl Pharmacol. 84(1):93-114
Materials and methods
- Principles of method if other than guideline:
- Mouse Ear Swelling Test (MEST)
- GLP compliance:
- not specified
- Type of study:
- mouse ear swelling test
Test material
- Reference substance name:
- Aluminium chloride
- EC Number:
- 231-208-1
- EC Name:
- Aluminium chloride
- Cas Number:
- 7446-70-0
- Molecular formula:
- AlCl3
- IUPAC Name:
- aluminum trichloride
- Details on test material:
- - Name of test material (as cited in study report): Aluminum chloride
- Analytical purity: at least 98%
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CF-1
- Sex:
- female
Study design: in vivo (non-LLNA)
Induction
- Route:
- epicutaneous, open
- Vehicle:
- other: 70% ethanol
- Concentration / amount:
- 10%
- Day(s)/duration:
- Day 0-3
Challenge
- No.:
- #1
- Route:
- epicutaneous, open
- Vehicle:
- other: 70% ethanol
- Concentration / amount:
- 10%
- Day(s)/duration:
- Day 10
- No. of animals per dose:
- Control group: at least 5
Test group: at least 10 - Details on study design:
- RANGE FINDING TESTS: concentration was reported to have been selected on the basis of irritation.
MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures: 4
- Exposure period: -
- Test groups: test substance in vehicle
- Control group: vehicle
- Site: clipped abdomen (after intradermal injection of Freund's Complete Adjuvant and tape-stripping)
- Frequency of applications: once per day
- Duration: days 0-3
- Concentrations: 10%
B. CHALLENGE EXPOSURE
- No. of exposures: 1
- Day(s) of challenge: day 10
- Exposure period: -
- Test groups: test substance in vehicle on the left ear; vehicle on the right ear
- Control group: test substance in vehicle on the left ear; vehicle on the right ear
- Site: ears
- Concentrations: 10%
- Evaluation (hr after challenge): 24 and 48 h
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Group:
- test chemical
- Dose level:
- 10%
- Remarks on result:
- no indication of skin sensitisation
Any other information on results incl. tables
Table 1. Results from the topical study
|
MEST results |
GPMT results |
Closed patch results |
Human results |
|
% sensitised |
% swelling |
||||
Aluminum chloride |
0 |
103 |
0 (1, 2) |
0 (1, 2) |
0 (1, 2) |
(1) Results are percentage sensitised
(2) Reported as literature value cited from Magnusson, B. and Kligman, A.M. (1969) J Invest Dermatol 52:268-276.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Conclusions:
- This publication describes the development and validation of the Mouse Ear Swelling Test for a number of known sensitisers and non-sensitisers and compares the results with available data from other testing systems (GPMT, Closed Patch Test, Human data). Under the conditions described in this study, aluminium chloride at 10% in 70% ethanol was not sensitising in the Mouse Ear Swelling Test, corroborating negative results previously published by Magnusson and Kligman (1969).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.