Registration Dossier
Registration Dossier
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EC number: 202-423-8 | CAS number: 95-48-7
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: patients with contact allergy were used
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Contact allergy to o-cresol - a sensitizer in phenol-formaldehyde resin.
- Author:
- Bruze M and E Zimerson
- Year:
- 2 002
- Bibliographic source:
- Am. J. Contact Dermatitis 13, 196-200
- Reference Type:
- publication
- Title:
- Cross-reaction patterns in patients with contact allergy to simple methylol phenols
- Author:
- Bruze M, Zimerson E
- Year:
- 1 997
- Bibliographic source:
- Contact Dermatitis 37, 82-86
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- other: patients with contact allergy
- Principles of method if other than guideline:
- Patch testing with patients.
- GLP compliance:
- no
Test material
- Reference substance name:
- o-cresol
- EC Number:
- 202-423-8
- EC Name:
- o-cresol
- Cas Number:
- 95-48-7
- Molecular formula:
- C7H8O
- IUPAC Name:
- o-cresol
- Details on test material:
- IUCLID4 Test substance: other TS: o-cresol, purity was confirmed by analytical HPLC, data not given
Constituent 1
Method
- Type of population:
- other: patients with contact allergy
- Ethical approval:
- not specified
- Subjects:
- 4 patients exposed (no further data)
- Clinical history:
- no data
- Controls:
- 20 healthy persons
- Route of administration:
- dermal
- Details on study design:
- no data
Results and discussion
- Results of examinations:
- no patient reacted to 0.81 mmol/l
3/4 reacted positive to 8.1 mmol/l
4/4 patients reacted positive to 81 mmol/l
no control person reacted to the test
Any other information on results incl. tables
no further data
Applicant's summary and conclusion
- Executive summary:
Patients suffering from contact alllergy were tested with o-cresol and revealed positive reactions.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
