Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
specific investigations: other studies
Adequacy of study:
other information

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed

Materials and methods

Principles of method if other than guideline:
Test procedure:
SPECIES/STRAIN: Cat


VEHICLE:

The substance was prepared as a 40% suspension in 0.1% Ivory
liquid (a non-toxic surfactant) in distilled water.


SEX DOSE (mg/kg) NUMBER OF NUMBER OF

ANIMALS DEATHS


M 4000 5 0


F 4000 5 0



SIGNS OF TOXICITY:

No treatment-related deaths or toxic signs were observed.


EFFECTS IN ORGANS:

One female cat treated with the test substance had a small
focal, oval grey lesion in the left eye on day 14. No other
eye effects as determined by both slit lamp and funduscopy
were observed in any of the other cats. Histopathological
examination of the eyes revealed a minimal focal plasma cell
infiltration of the bulbar conjunctivae of the left eye of
one cat treated with the substance.

Results and discussion

Details on results:
Not Classified


LD50: >4000 mg/kg

Applicant's summary and conclusion