Registration Dossier
Registration Dossier
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EC number: 402-130-7 | CAS number: 106246-33-7
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- adult fish: sub(lethal) effects
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
- Justification for type of information:
- JUSTIFICATION FOR DATA WAIVING
substance was found to be non-toxic at the solubility limit in the three acute aquatic toxicity studies on fish, Daphnia and algae; due to the poor water solubility, high log Pow and the lack of biodegradability, we propose to conduct a long-term toxicity study on an aquatic species; however as none of the three tested species showed effects in the acute tests, for animal welfare reasons we suggest to perform a reproduction test over 21 days on Daphnia magna.
Reference
Description of key information
Long-term toxicity on fish was waived. The test item was found to be non-toxic at the solubility limit in the three acute aquatic toxicity studies on fish, Daphnia and algae; due to the poor water solubility, high log Pow and the lack of biodegradability, we propose to conduct a long-term toxicity study on an aquatic species; however as none of the three tested species showed effects in the acute tests and could be identified as the most sensitive organism, for animal welfare reasons we suggest to perform a reproduction test over 21 days on Daphnia magna.
Key value for chemical safety assessment
Additional information
Source: GLP-report and expert assessment
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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