Registration Dossier
Registration Dossier
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EC number: 203-854-4 | CAS number: 111-29-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Internal BASF-method was used, which was in large part equivalent to methods described in OECD guideline 401
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Pentane-1,5-diol
- EC Number:
- 203-854-4
- EC Name:
- Pentane-1,5-diol
- Cas Number:
- 111-29-5
- Molecular formula:
- C5H12O2
- IUPAC Name:
- pentane-1,5-diol
- Details on test material:
- - Name of test material (as cited in study report): Pentandiol-1,5 techn.
- Physical state: liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Gassner
- Weight at study initiation: mean weight 205 g (male), 165 g (female)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 10%, 46.4%, 68.1%, 100%
- Amount of vehicle (if gavage): 6.8, 10.0 ml/kg bw
MAXIMUM DOSE VOLUME APPLIED: 10.0 ml/kg bw - Doses:
- 1000, 4640, 6810, 10000
- No. of animals per sex per dose:
- 1000 - 4640 mg/kg bw: 2 female
6810 - 10000 mg/kg bw: 5 male and 5 female - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: prior to study and at the end of study
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 10 000 mg/kg bw
- Mortality:
- 10000 mg/kg bw:
- male: 3/5 deaths within 24 h
- female: 0/5 deaths
6810 mg/kg bw:
- male: 0/5 deaths
- female: 1/5 deaths within 24 h
1000 - 4640 mg/kg bw: no deaths - Clinical signs:
- other: - reduced state and deaths observed on first 24 h - staggering, paresis, spastic gait, salivation, exsiccosis
- Gross pathology:
- Heart: acute dilatation, congestive hyperemia
Stomach: : bloody olcerations
Gut: diarrhotic content, hematonic content
Bladder: abnormal content
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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