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EC number: 203-854-4 | CAS number: 111-29-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
1,5 pentandiol is of low acute toxicity via all routes of exposure. The following lethal doses after acute exposures have been determined in the key studies:
- oral: LD50 = ca. 10000 mg/kg bw
- dermal: LD50 > 19800 mg/kg bw
- inhalative: no deaths within 7 h exposure to saturated vapor atmosphere(IRT)
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 10 000 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 19 800 mg/kg bw
Additional information
Acute oral toxicity was analyzed in a study, which was in large part equivalent to methods described in OECD guideline 401 (BASF, 1979). Two female Sprague-Dawley rats received doses of 1000 and 4640 mg/kg bw pentane-1,5-diol, while five males and five females were dosed by gavage with 6810 and 10000 mg/kg bw. Although three males of the highest dose group died within the 14 day observation period and some clinical signs including acute dilatation and congestive hyperemia were noted, the LD50 could be determined as ca. 10000 mg/kg bw.
In another study, five Carworth-Wistar rats per sex and dosed received pentane-1,5-diol by gastric intubation, resulting in a LD50 of 5890 mg/kg bw (Smyth, 1962).
The LD50 was estimated to be 2000 mg/kg bw for unspecific sex in rats, which was also confirmed by QSAR calculation (Frankenfeld, 1975; Wang, 1998). In another study the LD50 was found to be 6300 mg/kg bw for rabbits and guinea pig (Unknown, 1973).
To assess the acute inhalative toxicity, an inhalation risk test was conducted which was in large part equivalent to OECD guideline 403 (BASF, 1979). Six male and female Sprague-Dawley rats were exposed to saturated atmosphere of a vapor with 0.11 mg/kg pentane-1,5-diol for seven hours. Since no mortality as well as no obvious clinical signs was observed, subsequent calculation let to a LC0 of 0.078 mg/m3 air.
No mortality was also noted in another study, where six male and female albino rats were exposed to a vapor for eight hours (Smyth, 1962).
Acute dermal toxicity was evaluated in a study where 20 ml of pure pentane-1,5-diol was applied to the clipped skin of four New Zealand White rabbits under occlusion by an impervious plastic film (Smyth, 1962). Since no mortality was observed, the LD50 was >20 ml/kg bw corresponding to >19800 mg/kg bw.
In addition, five NMRI mice per sex and dose were intraperitoneal injected with doses of 1470, 2150, 3160 and 4640 mg/kg bw (BASF, 1979). Due to observed mortality in the 14 day observation period, the LD50 was estimated to be in range of 2100 – 3200 mg/kg bw.
In another study, a LD50 of 2246 mg/kg bw was found when six female ICR mice received pentane-1,5-diol by intraperitoneal injection (Holman, 1979).
Beside this, the LD50 in male Sprague-Dawley rats was found to be 3509 mg/kg bw after intraperitoneal injection of various doses (McCreery, 1978)
Justification for classification or non-classification
Due to the LD50 values obtained in several studies for acute oral, dermal and inhalative toxicity, no classification is required.
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