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EC number: 217-568-2
CAS number: 1889-67-4
The test item
1,1'-(1,1,2,2-tetramethylethylene)dibenzene was tested in an acute
dermal toxicity study in rats according to OECD guideline 402 and EU
method B.3. The test item was administered once topically on an area of
approximately 6.5 cm x 8 cm on the dorsal thoracic region of 5 male and
5 female Sprague Dawley rats. The dose was 2000 mg per kg body weight. A
cellulose patch with the calculated amount of the test substance on the
surface and soaked with deionised water to get optimal contact with the
skin, was applied to the test site and held in place by fixing
marginally with non-irritating tape. The test site was covered by a
semi-occlusive dressing. The duration of the exposure was 24 hours. No
local or systemic toxic effects related to administration of the test
substance were noted from clinical observations or post-mortem
examination at a dose of 2000 mg of the test substance per kg body
weight. No mortality occurred. Therefore, the LD50 dermal was estimated
to be > 2000 mg /kg body weight.
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