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Diss Factsheets
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EC number: 202-425-9 | CAS number: 95-50-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Original reference not translated
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- unknown
- Author:
- Bonnet P et al.
- Year:
- 1 979
- Bibliographic source:
- Archives des maladies professionnelles, de medecine du travail et de Securite Sociale (Paris) 40,805-810
- Reference Type:
- publication
- Title:
- unknown
- Author:
- Bonnet P et al.
- Year:
- 1 982
- Bibliographic source:
- Archives des maladies professionnelles, de medecine du travail et de Securite Sociale (Paris), 43, 261-265 (1982)
Materials and methods
- Principles of method if other than guideline:
- An acute toxicity study had been conducted on female mice. The LC50 was determined after inhalative exposure. The concentrations of the vaporised 1,2-dichlorobenzene were analysed regularly. The LC50 of 1,2-Dichlorobenzene was determinated in mice after 6 hour exposure.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- 1,2-dichlorobenzene
- EC Number:
- 202-425-9
- EC Name:
- 1,2-dichlorobenzene
- Cas Number:
- 95-50-1
- Molecular formula:
- C6H4Cl2
- IUPAC Name:
- 1,2-dichlorobenzene
- Details on test material:
- - Analytical purity: 99 %
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: OF1
- Sex:
- female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 6 h
- Concentrations:
- 1201-1279 ppm
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- 1 236 ppm
- Exp. duration:
- 6 h
Any other information on results incl. tables
LC50 = ca. 7.56 mg/L
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Executive summary:
Bonnet, 1979
An acute toxicity study had been conducted on female mice. The reliablility is not assignable because the publication is not translated. The LC50 was determined by inhalative exposure of female OF1 mice for 6 h. The concentrations (1201 - 1279 ppm) of the vaporised 1,2-dichlorobenzene were analysed regularly. A LC50 of 1236 ppm (7.55 mg/L) was stated. After conversion, the LC50 for 4h was 1854 ppm which results in an EU-GHS classification "Toxicity Category IV".
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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