Registration Dossier
Registration Dossier
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EC number: 202-425-9 | CAS number: 95-50-1
Endpoint summary
Administrative data
Description of key information
Additional information
Publications which investigate the toxicity of 1,2 -dichlorobenzene to earthworms and soil microorganisms are available. A filter paper test with the earthworm Eisenia fetida carried out according to OECD guideline 207 resulted in an LC50 of 21 µg/cm2. For soil microorganisms, a NOEC of >= 1 mg/g dry soil was obtained in a soil respiration test.
No test is available with terrestrial arthropods. However, a test on acute toxicity to earthworms (annelid) is available which is the species recommended by the OECD test guideline 207 for soil-dwelling organisms. The test is therefore not needed.
For terrestrial plants and birds, no studies conducted according to standard test methods are available.
According to the Regulation EC No 1907/2006 (REACH) Annex IX 9.4.3 column 2, the need of studies with terrestrial organisms depends on the outcome of the chemical safety assessment. As the predicted environmental concentration in soil is below the PNEC calculated using the equilibrium partitioning method (see chapter 9 and 10 of the chemical safety report for 1,2 -dichlorobenzene), a test on terrestrial plants is not needed.
According to chapter R16 of the "Guidance on information requirements and chemical safety assessment" published by ECHA (2008), a substance can be assessed in a first step based on classification on the basis of mammalian toxicity data whether it has a potential to cause toxic effects if accumulated in higher organisms. For substances that are classified as Very Toxic (T+) or Toxic (T) or harmful (Xn) with at least one of the risk phrases R48, R60, R61, R62, R63 or R64, secondary poisoning is a relevant route of exposure. As 1,2-dichlorobenzene is not classified as toxic or harmful, the substance is not considered to cause toxic effects in predators. Additionally, the measured BCF in fish was measured to be 260 and thus, 1,2-dichlorobenzene is considered to cause low hazard to predators. Thus, a study with birds is not needed due to animal welfare reasons.
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