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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
respiratory sensitisation: in vivo
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Original reference not translated (Russian)

Data source

Reference
Title:
No information
Author:
Shmuter, L.M. and Genes, V.S.: in Issues of experimental|and clinical pathology. (ed. T.V. Mitin). L vov; L vov|Medical Institute, 1980: IV 135-136: cited in Chloroben-|zenes (Series "Scientific Reviews of Soviet Literature of|Toxicity and Hazards of Chemicals"), edited by Izmerov,|N.F., Centre for International Projects, GKNT, Moscow, 1988;|data compiled by Vasilenko, N.M. and Semiletkina, N.N.|(number of issue: 108)

Materials and methods

Principles of method if other than guideline:
Rabbits were exposed via inhalation to o-dichlorobenzene at a concentration of 0.05 mg/l for 7 months (5 days a week, 4 hours daily).
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2-dichlorobenzene
EC Number:
202-425-9
EC Name:
1,2-dichlorobenzene
Cas Number:
95-50-1
Molecular formula:
C6H4Cl2
IUPAC Name:
1,2-dichlorobenzene

Test animals

Species:
rabbit

Test system

Route of induction exposure:
inhalation

Results and discussion

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
Sensitization became obvious at early stages of poisoning in the absence of any pointers to systemic toxic action; as the signs of intoxication developed, allergic tests became negative but again took on a positive value closer to the cessation of experiment; o-dichlorobenzene triggered the production of antibodies to erythrocyte lysate and of antitissue antibodies to autoantigenes from the renal tissue (no further data).
Executive summary:

Sensitization became obvious at early stages of poisoning in the absence of any pointers to systemic toxic action; as the signs of intoxication developed, allergic tests became negative but again took on a positive value closer to the cessation of experiment; o-dichlorobenzene triggered the production of antibodies to erythrocyte lysate and of antitissue antibodies to autoantigenes from the renal tissue (no further data).